Predicting the effects of degradation on viscoelastic relaxation time using model transient networks

IF 2.3 4区 化学 Q3 POLYMER SCIENCE Polymer Journal Pub Date : 2024-03-05 DOI:10.1038/s41428-024-00902-z
Ryunosuke Kobayashi, Mitsuru Naito, Kanjiro Miyata, Takamasa Sakai, Ung-il Chung, Takuya Katashima
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Abstract

In this study, we utilized tetra-armed polyethylene glycol (Tetra-PEG) slimes, which are model transient networks with well-controlled structures, to predict the effects of long-term degradation on the viscoelastic properties of liquids. Viscoelastic liquids, such as sodium hyaluronate, are frequently used in biomedical applications within the human body. However, precisely controlling the viscoelastic properties of these liquids in the long-term is challenging, as the main chains of the liquids undergo stochastic degradation. To establish a predictable model for studying long-term degradation effects, we employed Tetra-PEG slime, and modifications were performed to introduce specific cleavage sites in areas with connections. The Tetra-PEG slimes were characterized by single relaxation modes, and these modes were independent from the degree of degradation, which was determined by hydrolyzing the cleavage sites. Overall, this work provides a universal design for viscoelastic liquids with precisely-controllable degradation. This study explores the effects of long-term degradation on the viscoelastic properties of viscoelastic liquids using tetra-armed polyethylene glycol (Tetra-PEG) slimes as model material. It aims to enhance control over the viscoelasticity of biomedical materials, like sodium hyaluronate, by introducing specific cleavage sites into the Tetra-PEG slimes to simulate degradation. The study reveals that despite degradation, the slimes maintain a single relaxation mode, offering a method to design viscoelastic liquids with predictable and controllable degradation for biomedical applications.

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利用模型瞬态网络预测降解对粘弹性松弛时间的影响
在这项研究中,我们利用四臂聚乙二醇(Tetra-PEG)淤泥(具有良好结构的瞬态网络模型)来预测长期降解对液体粘弹性特性的影响。透明质酸钠等粘弹性液体经常用于人体的生物医学应用。然而,由于这些液体的主链会发生随机降解,因此长期精确控制这些液体的粘弹性能具有挑战性。为了建立一个研究长期降解效应的可预测模型,我们采用了四聚乙二醇(Tetra-PEG)粘液,并对其进行了改性,在有连接的区域引入了特定的裂解位点。Tetra-PEG 黏液以单一弛豫模式为特征,这些模式与降解程度无关,降解程度由水解裂解位点决定。总之,这项工作为可精确控制降解的粘弹性液体提供了一种通用设计。
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来源期刊
Polymer Journal
Polymer Journal 化学-高分子科学
CiteScore
5.60
自引率
7.10%
发文量
131
审稿时长
2.5 months
期刊介绍: Polymer Journal promotes research from all aspects of polymer science from anywhere in the world and aims to provide an integrated platform for scientific communication that assists the advancement of polymer science and related fields. The journal publishes Original Articles, Notes, Short Communications and Reviews. Subject areas and topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Polymer synthesis and reactions Polymer structures Physical properties of polymers Polymer surface and interfaces Functional polymers Supramolecular polymers Self-assembled materials Biopolymers and bio-related polymer materials Polymer engineering.
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