β-Glucan ameliorates cisplatin-induced oxidative and histological damage in kidney and liver of rats.

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnic & Histochemistry Pub Date : 2024-02-01 Epub Date: 2024-03-06 DOI:10.1080/10520295.2024.2320626

Kürşat Kaya, O Ciftci, N Basak Turkmen, A Taşlıdere, C C Gül

{"title":"β-Glucan ameliorates cisplatin-induced oxidative and histological damage in kidney and liver of rats.","authors":"Kürşat Kaya, O Ciftci, N Basak Turkmen, A Taşlıdere, C C Gül","doi":"10.1080/10520295.2024.2320626","DOIUrl":null,"url":null,"abstract":"<p><p>We investigated the effects of β-glucan (βg) on kidney and liver damage caused by cisplatin (CP), an antineoplastic agent widely used to treat many types of cancer, in a rat model. The side effects of CP in many tissues and organs limit its usage. βg is a natural polysaccharide that is an effective free radical scavenger. A total of 28 rats were randomly divided into four groups. Group 1 was a non-intervention control, only feed and water were given. Group 2 was administered 7 mg/kg CP in a single dose. Group 3 was administered 50 mg/kg βg orally for 14 days. Group 4 was administered βg for 14 days, following a single dose of CP. At the end of the experiment, kidney and liver tissues were evaluated biochemically and histopathologically. Increased thiobarbituric acid-reactive substances (TBARS) levels, as well as decreased catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and reduced glutathione (GSH) levels, as well as histological damage, were noted in both the kidney and liver tissues of the CP group. However, βg treatment prevented the oxidative and histopathological effects of CP. The study demonstrates the protective efficacy of βg against CP-induced kidney and liver damage through the effect of its antioxidant properties.</p>","PeriodicalId":8970,"journal":{"name":"Biotechnic & Histochemistry","volume":"99 2","pages":"92-100"},"PeriodicalIF":1.6000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnic & Histochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10520295.2024.2320626","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/6 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

We investigated the effects of β-glucan (βg) on kidney and liver damage caused by cisplatin (CP), an antineoplastic agent widely used to treat many types of cancer, in a rat model. The side effects of CP in many tissues and organs limit its usage. βg is a natural polysaccharide that is an effective free radical scavenger. A total of 28 rats were randomly divided into four groups. Group 1 was a non-intervention control, only feed and water were given. Group 2 was administered 7 mg/kg CP in a single dose. Group 3 was administered 50 mg/kg βg orally for 14 days. Group 4 was administered βg for 14 days, following a single dose of CP. At the end of the experiment, kidney and liver tissues were evaluated biochemically and histopathologically. Increased thiobarbituric acid-reactive substances (TBARS) levels, as well as decreased catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, and reduced glutathione (GSH) levels, as well as histological damage, were noted in both the kidney and liver tissues of the CP group. However, βg treatment prevented the oxidative and histopathological effects of CP. The study demonstrates the protective efficacy of βg against CP-induced kidney and liver damage through the effect of its antioxidant properties.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

β-葡聚糖可改善顺铂诱导的大鼠肝肾氧化损伤和组织损伤

我们在大鼠模型中研究了β-葡聚糖（βg）对顺铂（CP）引起的肾脏和肝脏损伤的影响，顺铂是一种广泛用于治疗多种癌症的抗肿瘤药物。顺铂对许多组织和器官的副作用限制了它的使用。βg 是一种天然多糖，是一种有效的自由基清除剂。研究人员将 28 只大鼠随机分为四组。第 1 组为非干预对照组，只给饲料和水。第 2 组单次给药 7 毫克/千克 CP。第 3 组连续 14 天口服 50 毫克/千克 βg。第 4 组在服用单剂量 CP 后，连续 14 天口服 βg。实验结束时，对肝肾组织进行生化和组织病理学评估。结果表明，氯化石蜡组的肾脏和肝脏组织中硫代巴比妥酸反应物质（TBARS）水平升高，过氧化氢酶（CAT）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）活性和还原型谷胱甘肽（GSH）水平降低，组织损伤也有所减轻。然而，βg 治疗可防止氯化石蜡的氧化作用和组织病理学影响。这项研究表明，βg 通过其抗氧化特性对氯化石蜡诱导的肾脏和肝脏损伤具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.