Inflammatory and Nutritional Biomarkers in Patients With Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemotherapy and Radiation Therapy.

IF 1.6 4区 医学 Q2 NURSING Oncology nursing forum Pub Date : 2024-02-19 DOI:10.1188/24.ONF.177-192
Chun Hou Huang, Bee Song Chang, Tai-Chu Peng, Yun-Hsin Peng
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Abstract

Objectives: To investigate the relationship between pretreatment inflammatory and nutritional biomarkers in patients with esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant chemotherapy and radiation therapy (nCRT).

Sample & setting: 213 patients with newly diagnosed stage II-III ESCC who received nCRT at an academic hospital in Taiwan.

Methods & variables: Electronic health record data were used. Records on inflammatory and nutritional biomarkers and clinical outcomes were extracted. Logistic regression analysis was used to predict treatment-related adverse events, Cox regression was used for survival outcomes, and receiver operating characteristic curve analysis was used to determine optimal cutoff values.

Results: There was a significant association between low prognostic nutritional index (PNI) and nCRT toxicities and survival. Advanced cancer stage, high platelet-to-lymphocyte ratio, and occurrence of pneumonia/infection were linked to survival outcomes.

Implications for nursing: PNI shows promise in predicting prognosis, helps identify high-risk patients, and enables nurses to apply tailored interventions.

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接受新辅助化疗和放疗的食管鳞状细胞癌患者的炎症和营养生物标志物
目的研究接受新辅助化疗和放疗(nCRT)的食管鳞状细胞癌(ESCC)患者治疗前炎症和营养生物标记物之间的关系:方法与变量:使用电子健康记录数据。方法与变量:使用电子健康记录数据,提取炎症和营养生物标志物以及临床结果的记录。采用 Logistic 回归分析预测治疗相关不良事件,采用 Cox 回归分析预测生存结果,采用接收者操作特征曲线分析确定最佳临界值:结果:低预后营养指数(PNI)与 nCRT 毒性和生存率之间存在明显关联。癌症晚期、高血小板淋巴细胞比值和肺炎/感染的发生与生存结果有关:营养指数有望预测预后,有助于识别高危患者,并使护士能够采取有针对性的干预措施。
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来源期刊
Oncology nursing forum
Oncology nursing forum 医学-护理
CiteScore
3.20
自引率
0.00%
发文量
76
审稿时长
>12 weeks
期刊介绍: The mission of the Oncology Nursing Forum, an official publication of ONS, is to Convey research information related to practice, technology, education, and leadership. Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care. Stimulate discussion of critical issues relevant to oncology nursing.
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