Upper Gastrointestinal Bleeding Secondary to Sodium Polystyrene Sulfonate Use: A Rare Adverse Effect of Commonly Prescribed Treatment.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY Case Reports in Gastrointestinal Medicine Pub Date : 2024-02-27 eCollection Date: 2024-01-01 DOI:10.1155/2024/6004323
Hamzah Shariff, Shiva Naidoo, Ghazal Ghafari, Hongjie Li, Manisha Devi, Kishore Kumar
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Abstract

We report a case of a 62-year-old man who was brought in by emergency medical services after a fall and change in mental status. He was found to have severe hyperkalemia, acute kidney injury, and rhabdomyolysis. The hyperkalemia was treated with sodium polystyrene sulfonate (SPS). During hospitalization, he witnessed having black tarry stools along with a significant drop in hemoglobin. Endoscopic evaluation demonstrated nonbleeding large diffuse gastric ulcers with stigmata of recent bleeding, and ulcer biopsy revealed findings consistent with SPS-induced gastric ulceration. No other source of bleeding was localized, suggesting acute upper gastrointestinal bleeding due to SPS mucosal injury.

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使用聚苯乙烯磺酸钠引起的上消化道出血:常见处方治疗的罕见不良反应。
我们报告了一个病例,一名 62 岁的男子因摔倒和精神状态改变而被紧急医疗服务人员送来。他被发现患有严重的高钾血症、急性肾损伤和横纹肌溶解症。高钾血症用聚苯乙烯磺酸钠(SPS)治疗。住院期间,他目睹了黑色柏油样粪便和血红蛋白的显著下降。内镜检查显示,他的胃部有不出血的大面积弥漫性溃疡,并有近期出血的痕迹,溃疡活检结果显示与 SPS 引起的胃溃疡一致。局部没有发现其他出血源,这表明急性上消化道出血是由 SPS 粘膜损伤引起的。
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来源期刊
Case Reports in Gastrointestinal Medicine
Case Reports in Gastrointestinal Medicine GASTROENTEROLOGY & HEPATOLOGY-
自引率
0.00%
发文量
33
审稿时长
14 weeks
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