A Short Update on the Use of Monoclonal Antibodies in COVID-19.

IF 5 3区 医学 Q1 PHARMACOLOGY & PHARMACY AAPS Journal Pub Date : 2024-03-05 DOI:10.1208/s12248-024-00904-y
Antonio Vitiello, Michela Sabbatucci, Annarita Ponzo, Antonio Salzano, Andrea Zovi
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Abstract

Monoclonal antibodies in the prophylaxis and treatment of COVID-19 have been crucial in reducing severe infections when vaccines were unavailable. However, as the virus and its variants have changed over time, the effectiveness of monoclonal antibodies has been questioned. This technical note highlights the need to assess the antiviral activity of these antibodies against new variants and adapt treatment strategies accordingly. On the one hand, in vitro studies have suggested reduced susceptibility of the latest variants to monoclonal antibodies, whereas clinical data still show benefits in reducing severe illness and mortality, indicating that laboratory results do not always mirror real-world outcomes. As a result, although resistance to monoclonal antibodies can develop over time, they could still have an important role in COVID-19 treatment, especially when used in combination, and ongoing research aims to identify effective antibodies against new variants.

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关于在 COVID-19 中使用单克隆抗体的简短更新。
在没有疫苗的情况下,用于预防和治疗 COVID-19 的单克隆抗体对减少严重感染至关重要。然而,随着病毒及其变种的不断变化,单克隆抗体的有效性也受到了质疑。本技术说明强调了评估这些抗体对新变种的抗病毒活性并相应调整治疗策略的必要性。一方面,体外研究表明最新变异株对单克隆抗体的敏感性降低,而临床数据仍显示这些变异株在降低重症和死亡率方面具有优势,这表明实验室结果并不总是反映真实世界的结果。因此,尽管随着时间的推移会产生对单克隆抗体的抗药性,但单克隆抗体在COVID-19的治疗中仍可发挥重要作用,尤其是在联合使用时。
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来源期刊
AAPS Journal
AAPS Journal 医学-药学
CiteScore
7.80
自引率
4.40%
发文量
109
审稿时长
1 months
期刊介绍: The AAPS Journal, an official journal of the American Association of Pharmaceutical Scientists (AAPS), publishes novel and significant findings in the various areas of pharmaceutical sciences impacting human and veterinary therapeutics, including: · Drug Design and Discovery · Pharmaceutical Biotechnology · Biopharmaceutics, Formulation, and Drug Delivery · Metabolism and Transport · Pharmacokinetics, Pharmacodynamics, and Pharmacometrics · Translational Research · Clinical Evaluations and Therapeutic Outcomes · Regulatory Science We invite submissions under the following article types: · Original Research Articles · Reviews and Mini-reviews · White Papers, Commentaries, and Editorials · Meeting Reports · Brief/Technical Reports and Rapid Communications · Regulatory Notes · Tutorials · Protocols in the Pharmaceutical Sciences In addition, The AAPS Journal publishes themes, organized by guest editors, which are focused on particular areas of current interest to our field.
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