Embigin Is Highly Expressed on CD4+ and CD8+ T Cells but Is Dispensable for Several T Cell Effector Responses.

Q3 Medicine ImmunoHorizons Pub Date : 2024-03-01 DOI:10.4049/immunohorizons.2300083
Haoran Yang, Naoki Iwanaga, Alexis R Katz, Andy R Ridley, Haiyan D Miller, Michaela J Allen, Dereck Pociask, Jay K Kolls
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Abstract

T cell immunity, including CD4+ and CD8+ T cell immunity, is critical to host immune responses to infection. Transcriptomic analyses of both CD4+ and CD8+ T cells of C57BL/6 mice show high expression the gene encoding embigin, Emb, which encodes a transmembrane glycoprotein. Moreover, we found that lung CD4+ Th17 tissue-resident memory T cells of C57BL/6 mice also express high levels of Emb. However, deletion of Emb in αβ T cells of C57BL/6 mice revealed that Emb is dispensable for thymic T cell development, generation of lung Th17 tissue-resident memory T cells, tissue-resident memory T cell homing to the lung, experimental autoimmune encephalitis, as well as clearance of pulmonary viral or fungal infection. Thus, based on this study, embigin appears to play a minor role if any in αβ T cell development or αβ T cell effector functions in C57BL/6 mice.

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Embigin在CD4+和CD8+T细胞上高表达,但在几种T细胞效应反应中是不可或缺的。
T 细胞免疫,包括 CD4+ 和 CD8+ T 细胞免疫,对于宿主对感染的免疫反应至关重要。对 C57BL/6 小鼠 CD4+ 和 CD8+ T 细胞的转录组分析表明,编码 Emb 的基因表达量很高,Emb 是一种跨膜糖蛋白。此外,我们还发现 C57BL/6 小鼠肺部 CD4+ Th17 组织驻留记忆 T 细胞也高水平表达 Emb。然而,在 C57BL/6 小鼠的 αβ T 细胞中缺失 Emb 后发现,Emb 对胸腺 T 细胞的发育、肺 Th17 组织驻留记忆 T 细胞的生成、组织驻留记忆 T 细胞归巢到肺、实验性自身免疫性脑炎以及清除肺部病毒或真菌感染都是不可或缺的。因此,根据这项研究,embigin似乎在C57BL/6小鼠的αβ T细胞发育或αβ T细胞效应功能中只起了很小的作用。
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CiteScore
3.70
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审稿时长
4 weeks
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