Synthesis of 1H-benzimidazoles via the condensation of o-phenylenediamines with DMF promoted by organic acid under microwave irradiation

IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC Synthetic Communications Pub Date : 2024-04-17 DOI:10.1080/00397911.2024.2324456
Wenjuan Li , Xiao Li , Hailong Hong , Ruijun Xie , Ning Zhu
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Abstract

An effective, green and eco-friendly method was developed to synthesize 1H-benzimidazole under microwave irradiation. The reactions of substituted o-phenylenediamine with DMF were efficiently promoted by butanoic acid, and the desired product 1H-benzimidazole derivatives were obtained in good to excellent yields. Compared with the conventional heating method, microwave irradiation significantly reduced the reaction time and improved the yields of the target products.

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微波辐照下有机酸促进邻苯二胺与 DMF 缩合合成 1H 苯并咪唑
开发了一种在微波辐照下合成 1H-苯并咪唑的有效、绿色和环保方法。取代的邻苯二胺与DMF的反应能有效地促进1H-苯并咪唑的合成。
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来源期刊
Synthetic Communications
Synthetic Communications 化学-有机化学
CiteScore
4.40
自引率
4.80%
发文量
156
审稿时长
4.3 months
期刊介绍: Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.
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