Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems.

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Drug Delivery and Translational Research Pub Date : 2024-12-01 Epub Date: 2024-03-07 DOI:10.1007/s13346-024-01559-0
Benjamin Rossier, Olivier Jordan, Eric Allémann, Carlos Rodríguez-Nogales
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Abstract

Nanocrystals and nanosuspensions have become realistic approaches to overcome the formulation challenges of poorly water-soluble drugs. They also represent a less-known but versatile platform for multiple therapeutic applications. They can be integrated into a broad spectrum of drug delivery systems including tablets, hydrogels, microneedles, microparticles, or even functionalized liposomes. The recent progresses, challenges, and opportunities in this field are gathered originally together with an informative case study concerning an itraconazole nanosuspension-in-hydrogel formulation. The translational aspects, historical and current clinical perspectives are also critically reviewed here to shed light on the incoming generation of nanocrystal formulations.

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纳米晶体和纳米悬浮液:从经典配方到先进给药系统的探索。
纳米晶体和纳米悬浮剂已成为克服水溶性差药物制剂难题的现实方法。纳米晶体和纳米悬浮剂还是一种鲜为人知的多功能治疗平台。它们可以被整合到各种给药系统中,包括片剂、水凝胶、微针、微颗粒甚至功能化脂质体。本文收集了这一领域的最新进展、挑战和机遇,并提供了有关伊曲康唑纳米悬浮水凝胶配方的案例研究。本文还对转化方面、历史和当前的临床视角进行了评论,以阐明新一代纳米晶体制剂。
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来源期刊
Drug Delivery and Translational Research
Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY
CiteScore
11.70
自引率
1.90%
发文量
160
期刊介绍: The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.
期刊最新文献
Local delivery of doxorubicin prodrug via lipid nanocapsule-based hydrogel for the treatment of glioblastoma. Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes. 3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release. Resveratrol-loaded invasome gel: A promising nanoformulation for treatment of skin cancer. Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery systems.
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