Intima-Media Thickness in the Carotid Bifurcation is Related to Silent Brain Infarction: A Cross-Sectional Study.

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE Journal of atherosclerosis and thrombosis Pub Date : 2024-09-01 Epub Date: 2024-03-07 DOI:10.5551/jat.64721
Yasuhiro Nishiyama, Toshiaki Otsuka, Katsuhito Kato, Yoshiyuki Saiki, Noriko Matsumoto, Kazumi Kimura
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Abstract

Aims: Carotid intima-media thickness (IMT) measurement is used to assess subclinical atherosclerosis. We aimed to examine the association between the maximum IMT by location and the occurrence of silent brain infarction (SBI).

Methods: Overall, 280 Japanese individuals (92 females, 52.6±5 years old) underwent a medical check-up at our hospital in Tokyo in 2015. Carotid IMT was measured at each site on ultrasound images (common carotid artery [CCA], internal carotid artery, or bifurcation). The risk factors for arterial dysfunction were evaluated. SBI was assessed using magnetic resonance imaging (MRI). The cross-sectional relationship between carotid maximum IMT and SBI was evaluated.

Results: Of the 280 individuals, 18 (6.4%) were diagnosed with SBI on MRI. The mean age of the SBI(-) and SBI(+) groups was 51.9±10.6 and 63.6±18.6 years, respectively. The correlation coefficients between the carotid maximum IMT at each location were very weak (correlation coefficient range: 0.180-0.253). The percentage of participants with SBI increased significantly with increasing maximum CCA and bIMT values. After adjusting for confounders, SBI was found to be significantly associated with the maximum bIMT (per 0.1-mm increase) (adjusted odds ratio [aOR], 1.10; 95% confidence interval [CI]: 1.03-1.17). When bIMT was categorized according to three groups (<1.0 mm, 1.0-<2.0 mm, and ≥ 2.0 mm), a significant SBI risk was also observed with an increase by each category of bIMT (aOR: 3.96, 95% CI: 1.63-9.52, P=0.002).

Conclusion: The maximum bIMT was found to be the main determinant of SBI. A significant SBI risk was associated with an increase in each category of the maximum bIMT. Therefore, the maximum bIMT might be a useful predictor of future stroke in Japanese stroke-free medical check-up participants.

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颈动脉分叉处内膜厚度与无症状脑梗死有关:一项横断面研究
目的:颈动脉内膜中层厚度(IMT)测量用于评估亚临床动脉粥样硬化。我们的目的是研究不同部位的最大内中膜厚度与无声脑梗塞(SBI)发生率之间的关系:2015年,280名日本人(92名女性,52.6±5岁)在东京的本医院接受了体检。在超声图像(颈总动脉[CCA]、颈内动脉或分叉处)的每个部位测量颈动脉内径。评估了动脉功能障碍的风险因素。使用磁共振成像(MRI)对 SBI 进行评估。评估了颈动脉最大IMT和SBI之间的横截面关系:结果:在 280 人中,有 18 人(6.4%)经磁共振成像确诊为 SBI。SBI(-)组和SBI(+)组的平均年龄分别为(51.9±10.6)岁和(63.6±18.6)岁。各部位颈动脉最大内径之间的相关系数非常弱(相关系数范围:0.180-0.253)。随着 CCA 和 bIMT 最大值的增加,患有 SBI 的参与者比例也明显增加。在对混杂因素进行调整后,发现 SBI 与最大 bIMT 值(每增加 0.1 毫米)显著相关(调整后的赔率 [aOR],1.10;95% 置信区间 [CI]:1.03-1.17)。当 bIMT 按三组(<1.0 mm、1.0-<2.0 mm 和≥2.0 mm)分类时,随着每组 bIMT 的增加,也观察到显著的 SBI 风险(aOR:3.96,95% CI:1.63-9.52,P=0.002):结论:最大 bIMT 是 SBI 的主要决定因素。结论:最大 bIMT 是决定 SBI 的主要因素。因此,最大 bIMT 可能是日本无中风体检者未来中风的有效预测指标。
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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
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