The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish

IF 2.4 4区 医学 Q3 NEUROSCIENCES Neuroscience Research Pub Date : 2024-08-01 DOI:10.1016/j.neures.2024.03.001
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Abstract

The serotonergic neurons in the raphe nucleus are implicated in various cognitive functions such as learning and emotion. In vertebrates, the raphe nucleus is divided into the dorsal raphe and the median raphe. In contrast to the abundance of knowledge on the functions of the dorsal raphe, the roles of the serotonergic neurons in the median raphe are relatively unknown. The studies using zebrafish revealed that the median raphe serotonergic neurons receive input from the two distinct pathways from the habenula and the IPN. The use of zebrafish may reveal the function of the Hb-IPN-median raphe pathway. To clarify the functions of the median raphe serotonergic neurons, it is necessary to distinguish them from those in the dorsal raphe. Most median raphe serotonergic neurons originate from rhombomere 2 in mice, and we generated the transgenic zebrafish which can label the serotonergic neurons derived from rhombomere 2. In this study, we found the serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project axons to the rostral dorsal pallium in zebrafish. This study suggests that this transgenic system has the potential to specifically reveal the function and information processing of the Hb-IPN-raphe-telencephalon circuit in learning.

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源自菱形丘 2 的血清素能神经元定位于斑马鱼的正中剑突区,并投射到背侧丘。
剑突核中的血清素能神经元与学习和情感等多种认知功能有关。在脊椎动物中,剑突核分为背侧剑突和正中剑突。与背侧剑突功能的丰富知识相比,中侧剑突的血清素能神经元的作用相对未知。利用斑马鱼进行的研究发现,正中饶舌神经元的血清素能神经元接受来自哈贝纳拉和IPN两条不同通路的输入。利用斑马鱼可能会揭示 Hb-IPN- 正中急腹症通路的功能。要弄清正中饶舌区血清素能神经元的功能,有必要将它们与背侧饶舌区的神经元区分开来。在小鼠中,大多数正中饶舌5-羟色胺能神经元起源于菱形丘2,而我们产生的转基因斑马鱼可以标记菱形丘2的5-羟色胺能神经元。在这项研究中,我们发现源自菱形丘2的5-羟色胺能神经元定位于斑马鱼的正中饶舌,并将轴突投射到喙背掌叶。这项研究表明,这种转基因系统有可能特异性地揭示 Hb-IPN- 油菜-延脑回路在学习中的功能和信息处理。
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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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