Antimüllerian hormone levels and IVF outcomes in polycystic ovary syndrome women: a scoping review.

IF 1.8 Q3 OBSTETRICS & GYNECOLOGY Jornal Brasileiro de Reproducao Assistida Pub Date : 2024-06-01 DOI:10.5935/1518-0557.20230059
Luciana Carvalho Delamuta, Georges Fassolas, João Antonio Dias Júnior, Luiz Fernando de Oliveira Henrique, Felipe Passos Martins Izzo, Carlos Roberto Izzo
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Abstract

Antimüllerian hormone (AMH) is a homodimeric glycoprotein secreted by granulosa cells from primary to large antral follicles, and it plays an important role in the regulation of early follicle growth. It is considered a reliable marker of ovarian reserve and a predictor of ovarian response to controlled stimulation. Polycystic ovary syndrome (PCOS) is an endocrine condition that affects women of reproductive age worldwide, and it is associated with high levels of AMH. PCOS patients may have worse maturation and fertilization rates compared to normo-ovulatory women. Some studies have demonstrated a positive correlation between AMH levels and qualitative aspects of assisted reproduction treatment; but it is not clear whether high levels of both serum and follicular fluid AMH in PCOS patients correlate with in vitro fertilization outcomes. We ran this scoping review of the literature to address this specific question. We comprehensively searched the databases PubMed and Cochrane Library until January 2023. We found that higher AMH levels are associated with higher oocyte yield, but PCOS patients tend to have fewer mature oocytes and impaired embryo quality and implantation rates. Pregnancy rates, however, are not affected by AMH levels or laboratorial outcomes. We also found that higher AMH levels are associated with worse PCOS features.

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多囊卵巢综合征妇女的抗缪勒氏管激素水平与试管婴儿结果:范围界定综述。
抗缪勒氏管激素(AMH)是由原发至大前卵泡的颗粒细胞分泌的一种同源二聚体糖蛋白,在调节早期卵泡生长中发挥着重要作用。它被认为是卵巢储备功能的可靠标志物,也是预测卵巢对控制性刺激反应的指标。多囊卵巢综合征(PCOS)是一种影响全球育龄妇女的内分泌疾病,它与高水平的 AMH 有关。与正常排卵的女性相比,多囊卵巢综合征患者的成熟度和受精率可能更低。一些研究表明,AMH水平与辅助生殖治疗的质量呈正相关;但目前尚不清楚多囊卵巢综合症患者血清和卵泡液中高水平的AMH是否与体外受精结果相关。为了解决这一具体问题,我们对相关文献进行了综述。我们全面检索了 PubMed 和 Cochrane Library 等数据库,直至 2023 年 1 月。我们发现,较高的 AMH 水平与较高的卵母细胞产量有关,但多囊卵巢综合症患者的成熟卵母细胞往往较少,胚胎质量和植入率也会受损。然而,妊娠率并不受 AMH 水平或分娩结果的影响。我们还发现,AMH 水平越高,多囊卵巢综合征的特征越差。
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来源期刊
CiteScore
3.30
自引率
6.70%
发文量
56
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