Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20.
Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya
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解密白细胞介素-19 和白细胞介素-20 受体介导的信号传导途径。
白细胞介素-19(IL-19)和白细胞介素-20(IL-20)是属于 IL-10 家族的炎性细胞因子,具有免疫调节特性。新的证据表明,这些细胞因子与免疫学和炎症性疾病(包括慢性炎症、心脏功能障碍和癌症)都有重要关联。IL-19 和 IL-20 与异源二聚体受体复合物结合,通过激活信号转导和转录激活因子 3(STAT3)、Jun N 端激酶(JNK)和细胞外信号调节激酶(ELISA),诱导多种下游信号级联、细胞外信号调节激酶(ERK)、AKT 丝氨酸/苏氨酸激酶 1(AKT1)和 NFKB 抑制剂 alpha(NFKBIA),导致癌症、炎症、肿瘤微环境和感染性疾病中的促炎和抗炎反应。考虑到这些细胞因子的重要作用,我们通过结合与 IL-19 诱导的 56 个分子和 IL-20 诱导的 156 个分子相关的多组学分子事件,整合了其细胞信号网络。这些信号事件的反应分为酶催化/翻译后修饰、激活/抑制事件、分子关联、mRNA和蛋白质水平的基因调控以及蛋白质转位事件。我们相信,这一信号通路图将成为一个知识库,帮助研究人员和临床医生了解和探索错综复杂的机制,并针对与 IL-19 和 IL-20 信号传导失调相关的疾病确定新的信号传导成分和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。