Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-06 DOI:10.1089/jir.2024.0009
Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya
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解密白细胞介素-19 和白细胞介素-20 受体介导的信号传导途径。
白细胞介素-19(IL-19)和白细胞介素-20(IL-20)是属于 IL-10 家族的炎性细胞因子,具有免疫调节特性。新的证据表明,这些细胞因子与免疫学和炎症性疾病(包括慢性炎症、心脏功能障碍和癌症)都有重要关联。IL-19 和 IL-20 与异源二聚体受体复合物结合,通过激活信号转导和转录激活因子 3(STAT3)、Jun N 端激酶(JNK)和细胞外信号调节激酶(ELISA),诱导多种下游信号级联、细胞外信号调节激酶(ERK)、AKT 丝氨酸/苏氨酸激酶 1(AKT1)和 NFKB 抑制剂 alpha(NFKBIA),导致癌症、炎症、肿瘤微环境和感染性疾病中的促炎和抗炎反应。考虑到这些细胞因子的重要作用,我们通过结合与 IL-19 诱导的 56 个分子和 IL-20 诱导的 156 个分子相关的多组学分子事件,整合了其细胞信号网络。这些信号事件的反应分为酶催化/翻译后修饰、激活/抑制事件、分子关联、mRNA和蛋白质水平的基因调控以及蛋白质转位事件。我们相信,这一信号通路图将成为一个知识库,帮助研究人员和临床医生了解和探索错综复杂的机制,并针对与 IL-19 和 IL-20 信号传导失调相关的疾病确定新的信号传导成分和治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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