Osteocytes and Paget's Disease of Bone.

IF 4.3 2区医学 Current Osteoporosis Reports Pub Date : 2024-04-01 Epub Date: 2024-03-08 DOI:10.1007/s11914-024-00863-5

Hirofumi Tenshin, Jesus Delgado-Calle, Jolene J Windle, G David Roodman, John M Chirgwin, Noriyoshi Kurihara

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Abstract

Purpose of review: To describe the contributions of osteocytes to the lesions in Paget's disease, which are characterized by locally overactive bone resorption and formation.

Recent findings: Osteocytes, the most abundant cells in bone, are altered in Paget's disease lesions, displaying increased size, decreased canalicular length, incomplete differentiation, and less sclerostin expression compared to controls in both patients and mouse models. Pagetic lesions show increased senescent osteocytes that express RANK ligand, which drives osteoclastic bone resorption. Abnormal osteoclasts in Paget's disease secrete abundant IGF1, which enhances osteocyte senescence, contributing to lesion formation. Recent data suggest that osteocytes contribute to lesion formation in Paget's disease by responding to high local IGF1 released from abnormal osteoclasts. Here we describe the characteristics of osteocytes in Paget's disease and their role in bone lesion formation based on recent results with mouse models and supported by patient data.

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骨细胞与骨质疏松症

综述的目的：描述骨细胞对 Paget 病病变的贡献，Paget 病的特点是局部骨吸收和形成过度活跃：骨细胞是骨中最丰富的细胞，在Paget病病变中发生了改变，与对照组相比，患者和小鼠模型中的骨细胞体积增大、管状长度减少、分化不完全、硬骨素表达较少。Pagetic病变中表达RANK配体的衰老骨细胞增多，而RANK配体可驱动破骨细胞的骨吸收。Paget 病中的异常破骨细胞会分泌大量 IGF1，从而促进骨细胞衰老，导致病变形成。最近的数据表明，成骨细胞通过对异常破骨细胞释放的大量局部 IGF1 作出反应，促成了 Paget 病病变的形成。在此，我们根据小鼠模型的最新结果，并在患者数据的支持下，描述了 Paget 病中成骨细胞的特征及其在骨病变形成中的作用。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

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期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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