Effects of bempedoic acid on markers of inflammation and Lp(a).

IF 2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Current Opinion in Cardiology Pub Date : 2024-07-01 Epub Date: 2024-03-04 DOI:10.1097/HCO.0000000000001137

Sukhila Reddy, Abhizith Deoker

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Abstract

Purpose of review: To study the effect of bempedoic acid on markers of inflammation and lipoprotein (a) to help determine if the drug would be useful to treat patients with elevated cardiovascular risks and residual cardiovascular risk despite optimal low-density lipoprotein cholesterol (LDL-C) levels.

Recent findings: Bempedoic acid is found to cause significant reduction in LDL-C and high-sensitivity C-reactive protein (hs-CRP) in various randomized clinical trials. Multiple meta-analyses have also found that bempedoic acid therapy leads to reduction in non-high-density lipoprotein cholesterol (non-HDL-C), total cholesterol (TC) and apolipoprotein B (ApoB) levels. However, it has minimal effect on lipoprotein (a) (Lp(a)) level.

Summary: Bempedoic acid is a new lipid-lowering agent that inhibits enzyme ATP-citrate lyase in the cholesterol biosynthesis pathway. Major risk of cardiovascular events and its associated morbidity and mortality are proportional to LDL-C and inflammatory markers levels. It was found that bempedoic acid significantly lowers LDL-C, hs-CRP and other inflammatory markers levels. This drug could potentially be used in patients with elevated cardiovascular risk, in patients with residual cardiovascular risk despite attaining LDL-C goal and in statin intolerant patients.

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鱼贝多酸对炎症指标和脂蛋白（a）的影响

综述目的：研究鱼腥草酸对炎症指标和脂蛋白（a）的影响，以帮助确定该药物是否有助于治疗心血管风险升高的患者，以及在低密度脂蛋白胆固醇（LDL-C）达到最佳水平后仍存在心血管风险的患者：最近的研究结果：在多项随机临床试验中发现，本鱼藤酸可显著降低低密度脂蛋白胆固醇和高敏C反应蛋白（hs-CRP）。多项荟萃分析还发现，双鱼藤酸疗法可降低非高密度脂蛋白胆固醇（non-HDL-C）、总胆固醇（TC）和载脂蛋白 B（ApoB）水平。摘要：鱼腥草酸是一种新型降脂药，可抑制胆固醇生物合成途径中的 ATP-柠檬酸酶。心血管事件的主要风险及其相关的发病率和死亡率与低密度脂蛋白胆固醇和炎症指标水平成正比。研究发现，贝门冬氨酸能明显降低低密度脂蛋白胆固醇、hs-CRP 和其他炎症指标的水平。这种药物可用于心血管风险升高的患者、已达到低密度脂蛋白胆固醇目标但仍有心血管风险的患者以及他汀类药物不耐受的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cardiology 医学-心血管系统

CiteScore

4.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.