Predictive utility of remnant cholesterol in atherosclerotic cardiovascular disease.

IF 2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Current Opinion in Cardiology Pub Date : 2024-07-01 Epub Date: 2024-03-08 DOI:10.1097/HCO.0000000000001140
Spencer D Proctor, Maggie Wang, Donna F Vine, Paolo Raggi
{"title":"Predictive utility of remnant cholesterol in atherosclerotic cardiovascular disease.","authors":"Spencer D Proctor, Maggie Wang, Donna F Vine, Paolo Raggi","doi":"10.1097/HCO.0000000000001140","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Remnant cholesterol (RC) is the cholesterol carried in lipoproteins derived from the catabolism of chylomicrons and very low-density lipoproteins. Evidence supporting the causal relationship of RC with atherosclerotic cardiovascular disease (ASVD) is accumulating rapidly. The number of impactful contributions to this field are increasing and provide a pathophysiological insight into the current residual cardiovascular risk beyond low-density cholesterol (LDL)-cholesterol (LDL-C). They also raise the question of whether RC should be used in prediction models and become the target of new therapeutic interventions. The intent of this review is to highlight the recent advances on the role of RC in atherogenesis and the validation of RC as a predictor of ASVD.</p><p><strong>Recent findings: </strong>Numerous prospective and retrospective cohorts helped validate a significant causal relationship of RC with various forms of ASVD, independent of LDL-C. A recent large Mendelian randomization study reinforced the existence of this relationship and showed that the risk of atherosclerotic events was driven nearly entirely by a direct effect of RC.</p><p><strong>Summary: </strong>Both available and accumulating evidence suggest that a lifelong reduction in RC could translate into a substantial reduction in ASVD risk. The data support a revision of current guidelines to incorporate RC as an independent risk factor for ASVD. We propose that early screening of RC should be implemented and that RC lowering should become the target of future drug developments.</p>","PeriodicalId":55197,"journal":{"name":"Current Opinion in Cardiology","volume":" ","pages":"300-307"},"PeriodicalIF":2.0000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HCO.0000000000001140","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/3/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose of review: Remnant cholesterol (RC) is the cholesterol carried in lipoproteins derived from the catabolism of chylomicrons and very low-density lipoproteins. Evidence supporting the causal relationship of RC with atherosclerotic cardiovascular disease (ASVD) is accumulating rapidly. The number of impactful contributions to this field are increasing and provide a pathophysiological insight into the current residual cardiovascular risk beyond low-density cholesterol (LDL)-cholesterol (LDL-C). They also raise the question of whether RC should be used in prediction models and become the target of new therapeutic interventions. The intent of this review is to highlight the recent advances on the role of RC in atherogenesis and the validation of RC as a predictor of ASVD.

Recent findings: Numerous prospective and retrospective cohorts helped validate a significant causal relationship of RC with various forms of ASVD, independent of LDL-C. A recent large Mendelian randomization study reinforced the existence of this relationship and showed that the risk of atherosclerotic events was driven nearly entirely by a direct effect of RC.

Summary: Both available and accumulating evidence suggest that a lifelong reduction in RC could translate into a substantial reduction in ASVD risk. The data support a revision of current guidelines to incorporate RC as an independent risk factor for ASVD. We propose that early screening of RC should be implemented and that RC lowering should become the target of future drug developments.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
残余胆固醇对动脉粥样硬化性心血管疾病的预测作用。
综述的目的:残余胆固醇(RC)是乳糜微粒和极低密度脂蛋白分解产生的脂蛋白中携带的胆固醇。支持残余胆固醇与动脉粥样硬化性心血管疾病(ASVD)之间因果关系的证据正在迅速积累。该领域有影响力的研究成果越来越多,它们从病理生理学角度揭示了当前低密度胆固醇(LDL)-胆固醇(LDL-C)之外的残余心血管风险。这些研究还提出了一个问题:RC 是否应被用于预测模型并成为新的治疗干预措施的目标。本综述旨在突出 RC 在动脉粥样硬化发生过程中的作用以及 RC 作为 ASVD 预测指标的验证方面的最新进展:大量前瞻性和回顾性队列研究帮助验证了 RC 与各种形式的 ASVD 之间的显著因果关系,而与低密度脂蛋白胆固醇无关。最近的一项大型孟德尔随机研究进一步证实了这种关系的存在,并表明动脉粥样硬化事件的风险几乎完全由 RC 的直接影响所驱动。总结:现有和不断积累的证据表明,终生降低 RC 可大幅降低 ASVD 风险。这些数据支持对现行指南进行修订,将 RC 作为 ASVD 的一个独立风险因素。我们建议对 RC 进行早期筛查,并将降低 RC 作为未来药物开发的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Current Opinion in Cardiology
Current Opinion in Cardiology 医学-心血管系统
CiteScore
4.20
自引率
4.30%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.
期刊最新文献
Electrographic flow mapping of atrial fibrillation. Ablation options for sub-epicardially located ventricular substrates responsible for ventricular tachycardia: where is it all headed? Rethinking atherosclerotic cardiovascular disease prevention in the era of expanding therapies: could plaque stabilization reduce the need for lifelong treatments and polypharmacy? The management of new-onset atrial fibrillation in critical illness: an update on current therapeutic options. Advancements in automated external and wearable cardiac defibrillators.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1