A Tale of a Trail on How It Takes 5 Days of Kawasaki Disease to Initiate Coronary Artery Injury and Change the Lives of Children.

IF 1.3 Q3 PEDIATRICS Turkish archives of pediatrics Pub Date : 2024-03-01 DOI:10.5152/TurkArchPediatr.2024.23254
Nigah Dahdah
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Abstract

Many articles written on Kawasaki disease explain the disease and the history of an acute inflammatory dysregulation that typically affects preschool children and does not spare older ones. Six decades have passed since the discovery of the disease in Japan, yet there are parts of the world where the disease passes unacknowledged, diagnosis is delayed, or basic treatments are not readily available. The burden of Kawasaki disease is on every health-care provider who attends to children's health. It takes 5 days for the disease to initiate coronary artery injury in a child's heart, compared to 5 decades of lifetime atherosclerosis. Challenges facing patients, families, and physicians may not be overcome unless we advocate for the disease recognition and seek support for affordable, timely treatment, impactful research, and dissemination of knowledge. The purpose of this review is to provide a comprehensive review of the history of Kawasaki disease and how it has affected children's health worldwide over the last 6 decades. The review also raises current challenges facing the fight against Kawasaki disease. In an effort to bring Kawasaki disease advocates together in a landing zone, an internet hub for Kawasaki disease experts and enthusiasts has been created: the International Kawasaki Disease Society (presently a concept idea) and a dedicated website, www.ikds-org.

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一个关于川崎病如何在 5 天内引发冠状动脉损伤并改变儿童生命的小径故事。
许多关于川崎病的文章都解释了这种疾病以及急性炎症失调的历史,这种疾病通常会影响学龄前儿童,也不会放过年龄较大的儿童。自日本发现川崎病以来,60 年过去了,但世界上仍有一些地方的川崎病不为人知,诊断被延误,或无法获得基本治疗。川崎病给每一位关注儿童健康的医护人员带来了沉重的负担。川崎病只需 5 天就能造成儿童心脏冠状动脉损伤,而一生中动脉粥样硬化的时间则长达 50 年。除非我们倡导对该疾病的认识,并为负担得起的及时治疗、有影响力的研究和知识传播寻求支持,否则患者、家属和医生面临的挑战可能无法克服。本综述旨在全面回顾川崎病的历史及其在过去 60 年中如何影响全球儿童的健康。本综述还提出了当前抗击川崎病所面临的挑战。为了将川崎病的拥护者聚集在一个着陆区,我们创建了一个川崎病专家和爱好者的互联网中心:国际川崎病协会(目前只是一个概念)和一个专门的网站 www.ikds-org。
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