Review on Kidney-Liver Crosstalk: Pathophysiology of Their Disorders.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-02-01 DOI:10.22074/cellj.2023.2007757.1376

Niloofar Khoshdel Rad, Zahra Heydari, Amir Hossein Tamimi, Ensieh Zahmatkesh, Anastasia Shpichka, Maryam Barekat, Peter Timashev, Nikoo Hossein-Khannazer, Moustapha Hassan, Massoud Vosough

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Abstract

Kidney-liver crosstalk plays a crucial role in normal and certain pathological conditions. In pathologic states, both renal-induced liver damage and liver-induced kidney diseases may happen through these kidney-liver interactions. This bidirectional crosstalk takes place through the systemic conditions that mutually influence both the liver and kidneys. Ischemia and reperfusion, cytokine release and pro-inflammatory signaling pathways, metabolic acidosis, oxidative stress, and altered enzyme activity and metabolic pathways establish the base of this interaction between the kidneys and liver. In these concomitant kidney-liver diseases, the survival rates strongly correlate with early intervention and treatment of organ dysfunction. Proper care of a nephrologist and hepatologist and the identification of pathological conditions using biomarkers at early stages are necessary to prevent the complications induced by this complex and potentially vicious cycle. Therefore, understanding the characteristics of this crosstalk is essential for better management. In this review, we discussed the available literature concerning the detrimental effects of kidney failure on liver functions and liver-induced kidney diseases.

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肾脏与肝脏相互关系综述：病理生理学。

肾脏与肝脏之间的相互作用在正常和某些病理状态下都起着至关重要的作用。在病理状态下，肾脏引起的肝脏损伤和肝脏引起的肾脏疾病都可能通过这些肝肾相互作用而发生。这种双向串联是通过对肝脏和肾脏产生相互影响的系统条件来实现的。缺血和再灌注、细胞因子释放和促炎症信号通路、代谢性酸中毒、氧化应激以及酶活性和代谢通路的改变为肾脏和肝脏之间的相互作用奠定了基础。在这些并发的肝肾疾病中，存活率与早期干预和治疗器官功能障碍密切相关。肾脏病学家和肝脏病学家的适当护理，以及在早期阶段利用生物标记物识别病理状况，对于预防这种复杂且潜在的恶性循环所引发的并发症是十分必要的。因此，了解这种串联的特点对于更好地管理至关重要。在这篇综述中，我们讨论了有关肾衰竭对肝功能的不利影响以及肝脏诱发肾脏疾病的现有文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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