Chemometric Optimization of SPE for the Determination of Multiclass Pesticides in Portable Water Samples by UHPLC-MS/MS.

IF 2.7 4区环境科学与生态学 Q3 ENVIRONMENTAL SCIENCES Bulletin of Environmental Contamination and Toxicology Pub Date : 2024-03-09 DOI:10.1007/s00128-024-03873-2

Garyfallia Drimaropoulou, Christophoros Christophoridis, Constantinos K Zacharis, Konstantinos Fytianos

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Abstract

This study aimed on the development of a SPE-UHPLC-MS/MS method for the simultaneous determination of pesticide residues in drinking water samples. A chemometric approach was applied to optimize the efficiency of the SPE pretreatment procedure. This study involved (i) the application of a Full Factorial Design for the screening of the significant factors, (ii) the application of a Central Composite Design for the determination of the optimal conditions and (iii) the evaluation and validation of the significance of the statistically proposed models. Oasis HLB cartridges were used for the extraction. The optimum sample volume was 300 mL and the elution solvent 3 mL of the mixture of methanol:ethylacetate 70:30 v/v. The method was validated according to the international guidelines. Recoveries were ranged from 63 to 116% and the detection limits were between 0.1 and 1.5 pg mL^- 1. The validated method could be used in routine analysis for pesticides screening.

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超高效液相色谱-质谱/质谱法测定便携式水样中多类农药的 SPE 化学计量学优化。

本研究旨在建立一种 SPE-UHPLC-MS/MS 方法，用于同时测定饮用水样品中的农药残留。采用化学计量学方法优化了 SPE 预处理程序的效率。该研究包括：(i) 应用全因子设计筛选重要因素；(ii) 应用中央复合设计确定最佳条件；(iii) 评估和验证统计模型的重要性。使用 Oasis HLB 滤芯进行萃取。最佳样品量为 300 毫升，洗脱溶剂为 3 毫升甲醇：乙酸乙酯 70:30 v/v 的混合物。该方法根据国际指南进行了验证。回收率为 63% 至 116%，检出限为 0.1 至 1.5 pg mL-1。该方法可用于农药筛选的常规分析。

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来源期刊

Bulletin of Environmental Contamination and Toxicology 环境科学-毒理学

CiteScore

5.60

自引率

3.70%

发文量

230

审稿时长

1.7 months

期刊介绍： The Bulletin of Environmental Contamination and Toxicology(BECT) is a peer-reviewed journal that offers rapid review and publication. Accepted submissions will be presented as clear, concise reports of current research for a readership concerned with environmental contamination and toxicology. Scientific quality and clarity are paramount.