Synthesis of hydantoins from N-Boc protected amino acid derived amides using polymer-supported PPh3/CBr4 as a reagent

Abstract

Hydantoin derivatives are versatile structural motifs found in natural products and various compounds with different biological or other properties. Due to their importance in both organic and medicinal chemistry, a number of synthetic procedures have been developed. In this article, a novel methodology utilizing N-Boc protected amino acid amides for their preparation has been described. The cyclisation process was accomplished using solid supported PPh₃ and CBr₄ as reagents affording substituted hydantoins in moderate to good yields (40%–77%).