A. V. Pekshev, A. B. Vagapov, N. A. Sharapov, A. F. Vanin
{"title":"Inhalation of High Doses of Gaseous Nitric Oxide in HIV Infection","authors":"A. V. Pekshev, A. B. Vagapov, N. A. Sharapov, A. F. Vanin","doi":"10.1134/s0006350923050196","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The therapeutic effect of high-dose inhalation of nitrogen oxide gas (at a NO concentration of at least 1000 ppm) in two HIV-infected patients was demonstrated. Inhaled NO therapy led to a rapid decrease in viral load to an undetectable level, which persisted even after the period of analytical interruption of treatment. It was assumed that the relief of HIV infection was due to nitrosonium cations NO<sup>+</sup> formed in the blood from neutral NO molecules. The subsequent conversion of NO<sup>+</sup> cations in their reaction with hydroxyl anions into nitrite anions was prevented by the binding of NO<sup>+</sup> cations with chlorine anions and the formation of nitrosochloride in the blood. The entry of this agent from the blood into cells and tissues provided the transfer of NO<sup>+</sup> cations into them. The interaction of nitrosochloride with thiols could lead to the appearance of corresponding S-nitrosothiols in cells and tissues as NO donors.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":null,"pages":null},"PeriodicalIF":4.0330,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://doi.org/10.1134/s0006350923050196","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The therapeutic effect of high-dose inhalation of nitrogen oxide gas (at a NO concentration of at least 1000 ppm) in two HIV-infected patients was demonstrated. Inhaled NO therapy led to a rapid decrease in viral load to an undetectable level, which persisted even after the period of analytical interruption of treatment. It was assumed that the relief of HIV infection was due to nitrosonium cations NO+ formed in the blood from neutral NO molecules. The subsequent conversion of NO+ cations in their reaction with hydroxyl anions into nitrite anions was prevented by the binding of NO+ cations with chlorine anions and the formation of nitrosochloride in the blood. The entry of this agent from the blood into cells and tissues provided the transfer of NO+ cations into them. The interaction of nitrosochloride with thiols could lead to the appearance of corresponding S-nitrosothiols in cells and tissues as NO donors.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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