Evaluation of the Efficiency of Intersystem Crossing to a Triplet State of Fullerene in Complexes with Amino Acids

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-07 DOI:10.1134/S000635092305007X
A. S. Buchelnikov, P. A. Sokolov, R. R. Ramasanoff
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Abstract

The important photophysical process that determines the efficiency of photosensitizers is saturation of the triplet state through the intersystem crossing during light absorption. We studied the C60 fullerene complexes with the amino acids (glycine, lysine, methionine, and threonine) as promising photosensitizers. The calculations for all these complexes demonstrate high values of the transition rate constants to the triplet states and a high probability of generating reactive oxygen species upon excitation in visible light. The carboxyl groups of amino acids, which are not involved in electronic excitation, can be used to conjugate photoactive complexes with a tumor-targeting drug delivery system, such as specific DNA aptamers.

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评估富勒烯与氨基酸复合物的三重态系统间交叉效率
摘要 决定光敏剂效率的重要光物理过程是在光吸收过程中通过系统间交叉使三重态饱和。我们研究了 C60 富勒烯与氨基酸(甘氨酸、赖氨酸、蛋氨酸和苏氨酸)的配合物,它们是很有前途的光敏剂。对所有这些复合物的计算都表明,它们向三重态转变的速率常数很高,在可见光下激发时产生活性氧的概率也很高。氨基酸的羧基不参与电子激发,可用于将光敏复合物与肿瘤靶向药物输送系统(如特异性 DNA aptamers)结合在一起。
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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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