A Study on the Radiosensitivity and Induction of Adaptive Response in Peripheral Blood Lymphocytes of Patients with Secondary Immunodeficiency Syndrome

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-07 DOI:10.1134/S000635092305024X
O. M. Rozanova, E. N. Smirnova, T. A. Belyakova, N. S. Strelnikova
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Abstract

This study examined radiosensitivity to low- and high-dose exposure to X-rays in human lymphocytes and the ability of low and high radiation doses to induce radioadaptive response when peripheral blood cells from patients with secondary immune deficiency syndrome and healthy donors of different ages were irradiated in vitro. The occurrence of micronuclei in cytochalasin-blocked binucleated lymphocytes in culture served as an indication of cytogenetic damage. It was found that the spontaneous level of cytogenetic damage in blood lymphocytes of patients with secondary immune deficiency syndrome was 2.5 times greater than in healthy young and older volunteers, and there was also a substantial interindividual variability in the outcome parameters as compared to the data of control groups. There were no differences in the mean values for radiosensitivity to low- and high-dose exposure to X-rays between the groups. In all groups, no correlation was shown between the spontaneous level of micronuclei in lymphocytes and the radiosensitivity of individuals. The adaptive response was induced with the same frequency and to the same extent in lymphocytes in patients with secondary immune deficiency syndrome and in healthy donors of different ages.

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继发性免疫缺陷综合征患者外周血淋巴细胞的放射敏感性和适应性反应诱导研究
摘要 这项研究考察了人体淋巴细胞对低剂量和高剂量 X 射线照射的辐射敏感性,以及不同年龄的继发性免疫缺陷综合征患者和健康供体的外周血细胞在体外照射时,低剂量和高剂量辐射诱导辐射适应反应的能力。细胞毒素阻断的双核淋巴细胞在培养过程中出现的微核是细胞遗传损伤的标志。研究发现,继发性免疫缺陷综合征患者血液淋巴细胞自发的细胞遗传损伤程度是健康青年和老年志愿者的 2.5 倍,与对照组数据相比,结果参数的个体间差异也很大。各组之间对低剂量和高剂量 X 射线照射的辐射敏感性平均值没有差异。在所有组别中,淋巴细胞自发微核水平与个体的辐射敏感性之间没有相关性。继发性免疫缺陷综合征患者和不同年龄的健康供体的淋巴细胞诱发适应性反应的频率和程度相同。
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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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