{"title":"Detection of Hepatoma Serum Marker CD105 with Hemin/Graphene/Aptamer Nanoprobes","authors":"Desong Xia, Xiyu Liu, Yuhan Liao, Huiling Wang, Yanmei Li, Jian He, Jing Zhang, Liping Zhong, Yuhuan Wang","doi":"10.1166/jbn.2024.3791","DOIUrl":null,"url":null,"abstract":"CD105 is a serum marker of hepatoma. In this study, we established a stable detection platform constructed using a hemin-graphene-aptamer complex (HGN-apt) by optimizing the ratio of graphene, hemin, and aptamer. We also optimized CD105 detection conditions. The detection limit of this\n platform is 5.5 ng/mL, enabling sensitive detection of CD105. These experiments facilitate an innovative approach for the construction of a detection platform with high sensitivity and an expanded detection range using an HGN-apt probe, enabling specific detection of the serum hepatoma marker\n CD105. Our findings provide an important foundation for early diagnosis of hepatomas, and would therefore help to alleviate patient suffering, including mental and economic burdens. Our platform also offers a quantitative indicator for the prognosis of hepatomas.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"15 2","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1166/jbn.2024.3791","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
CD105 is a serum marker of hepatoma. In this study, we established a stable detection platform constructed using a hemin-graphene-aptamer complex (HGN-apt) by optimizing the ratio of graphene, hemin, and aptamer. We also optimized CD105 detection conditions. The detection limit of this
platform is 5.5 ng/mL, enabling sensitive detection of CD105. These experiments facilitate an innovative approach for the construction of a detection platform with high sensitivity and an expanded detection range using an HGN-apt probe, enabling specific detection of the serum hepatoma marker
CD105. Our findings provide an important foundation for early diagnosis of hepatomas, and would therefore help to alleviate patient suffering, including mental and economic burdens. Our platform also offers a quantitative indicator for the prognosis of hepatomas.
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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