A laboratory-based cross-sectional study about helicobacter pylori infection and diabetes.

Pub Date : 2024-01-01 DOI:10.22088/cjim.15.1.20

Mehrdad Haghighi, Mehdi Goudarzi, Abdolreza Babamahmoodi

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Abstract

Background: Despite the numerous articles discussing the relationship between diabetes mellitus type 2 (DMT2) and chronic Helicobacter pylori (H. pylori) infection the results have been inconsistent, necessitating further research. This study investigated the coexistence of Helicobacter pylori infection and DMT2.

Methods: We conducted a study in selected laboratories in Tehran, measuring the H.Pylori stool antigen (HpSA) in individuals referred by physicians for a glycosylated hemoglobin A1c (HbA1c) test.

Results: Out of the 2500 patients who were referred to randomly selected laboratories, a total of 2025 (81%) patients had serum HbA1c levels above 6.5%. of 2025 patients with HbA1c levels above 6.5%, 1321 (52.84%) had HpSA in their stool. No significant gender difference was observed, with a mean age ± SD, 48.65 ± 7.55. HpSA was positive in 52.84% of the DM group, while in the non-DM group, HpSA was positive in 37.36% of cases. Fecal antigen titers are not related to gender (P = 0.274) but are related to age (r = 0.213, P=0.034).

Conclusion: Long-term infection with Helicobacter pylori may be significantly associated with elevated HgA1c.Testing for H. pylori infection, regular monitoring of blood sugar and HbA1c levels in high-risk people can prevent DMT2.

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一项关于幽门螺旋杆菌感染与糖尿病的实验室横断面研究。

背景：尽管有许多文章讨论了2型糖尿病（DMT2）与慢性幽门螺旋杆菌（H. pylori）感染之间的关系，但结果并不一致，因此有必要进行进一步研究。本研究调查了幽门螺旋杆菌感染与 DMT2 同时存在的情况：我们在德黑兰的部分实验室开展了一项研究，测量由医生转介进行糖化血红蛋白 A1c（HbA1c）检测的患者的幽门螺杆菌粪便抗原（HpSA）：在随机抽取的 2500 名转诊患者中，共有 2025 名（81%）患者的血清 HbA1c 水平高于 6.5%。在 2025 名 HbA1c 水平高于 6.5%的患者中，有 1321 名（52.84%）患者的粪便中含有 HpSA。平均年龄为（48.65 ± 7.55）岁，无明显性别差异。在 DM 组中，52.84% 的病例 HpSA 呈阳性，而在非 DM 组中，37.36% 的病例 HpSA 呈阳性。粪便抗原滴度与性别无关（P=0.274），但与年龄有关（r=0.213，P=0.034）：幽门螺杆菌的长期感染可能与 HgA1c 升高有显著关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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