Normothermic regional perfusion procurement for abdominal organ donors: techniques and troubleshooting.

IF 1.8 4区医学 Q3 TRANSPLANTATION Current Opinion in Organ Transplantation Pub Date : 2024-06-01 Epub Date: 2024-03-11 DOI:10.1097/MOT.0000000000001140

Stephanie Silpe, Eric Martinez, Anji Wall

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Abstract

Purpose of review: Normothermic regional perfusion (NRP) is a novel procurement technique for donation after circulatory death (DCD) in the United States. It was pioneered by cardiothoracic surgery programs and is now being applied to abdominal-only organ donors by abdominal transplant programs. Multiple technical approaches can be used for abdominal-only NRP DCD donors and this review describes these techniques.

Recent findings: NRP has been associated with higher utilization of organs, particularly liver and heart grafts, from DCD donors and with better recipient outcomes. There are lower rates of delayed graft function in kidney transplant recipients and lower rates of ischemic cholangiopathy in liver transplant recipients. These benefits are driving increased interest from abdominal transplant programs in using NRP for DCD procurements.

Summary: This paper describes the technical aspects of NRP DCD that allow for maximization of its use based on different donor and policy characteristics.

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为腹部器官捐献者进行常温区域灌注采购：技术和故障排除。

审查目的：在美国，常温区域灌注（NRP）是一种用于循环死亡（DCD）后捐献的新型采购技术。该技术由心胸外科项目首创，目前腹腔移植项目正将其应用于腹腔器官捐献者。多种技术方法可用于腹部 NRP DCD 供体，本综述介绍了这些技术：最近的研究结果：NRP 与更高的 DCD 供体器官（尤其是肝脏和心脏移植物）利用率和更好的受体预后有关。肾移植受者移植功能延迟率较低，肝移植受者缺血性胆管病变率较低。摘要：本文介绍了 NRP DCD 的技术方面，根据不同的捐献者和政策特点，最大限度地利用 NRP DCD。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.

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