Combined microfocused ultrasound and delicate pulsed light for facial rejuvenation: A prospective, randomized, and split-face study

IF 2.2 3区医学 Q2 DERMATOLOGY Lasers in Surgery and Medicine Pub Date : 2024-03-10 DOI:10.1002/lsm.23777

Yawen Wang MB, Jingchen Liang MB, Ying Chen MB, Jun Xia MD, Yanting Liu MD, Jing Liu MD, Youbao Li MB, Mengyao Yang MB, Zhao Wang MD, PhD, Weihui Zeng MB

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Abstract

Objectives

Public's interest in noninvasive skin rejuvenation treatments continues to grow. The advantage of combination therapy lies in that it can target different aspects of skin rejuvenation. This study aimed to assess the efficacy and safety of microfocused ultrasound (MFU) combined with delicate pulsed light (DPL) for facial rejuvenation.

Methods

Twenty-one patients with facial relaxation were enrolled. All patients received whole-face MFU treatment, and one side of the face was randomly assigned to receive DPL. MFU treatment was performed at Months 0 and 3, while DPL treatment was performed at Months 1, 2, 4, and 5. The length and angle of the nasolabial fold and perioral wrinkles, melanin index (MI), erythema index (EI), transepidermal water loss (TEWL), and follow-up time were recorded at Months 0, 3, and 6. Side effects were recorded during treatment and each follow-up visit.

Results

Twenty patients successfully completed the study. At the sixth month, the average length of perioral wrinkles and nasolabial folds on the combined side decreased by 11.5% (p_within < 0.001) and 6.5% (p_within = 0.011), while 8.3% (p_within = 0.012) and 3.8% (p_within = 0.02) on the MFU side. Compared with MFU treatment alone, the combined treatment also showed significant improvements in nasolabial fold angle (from 28.8 ± 3.4° to 32.7 ± 5.0°) and perioral wrinkle angle (from 39.3 ± 5.0° to 43.7 ± 5.1°). In addition, the combined side had greater benefits than the MFU side in improving MI, EI, TEWL, and skin elasticity (p_between < 0.05). Except for one patient who withdrew due to increased skin sensitivity after MFU treatment, other subjects did not experience permanent or serious side effects.

Conclusions

The combination of MFU and DPL for facial rejuvenation treatment is safe and effective. The combined treatment has better efficacy in skin firmness, and improving skin tone.

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微聚焦超声波和精细脉冲光联合用于面部年轻化：一项前瞻性、随机和分脸研究。

目的：公众对非侵入性嫩肤疗法的兴趣与日俱增。联合疗法的优势在于它可以针对皮肤年轻化的不同方面。本研究旨在评估微聚焦超声波（MFU）与精细脉冲光（DPL）联合治疗面部年轻化的有效性和安全性：方法：21 名面部松弛患者入选。方法：21 名面部松弛症患者入组，所有患者均接受全脸 MFU 治疗，一侧面部随机分配接受 DPL 治疗。在第 0 个月和第 3 个月进行 MFU 治疗，在第 1、2、4 和 5 个月进行 DPL 治疗。在第 0、3 和 6 个月记录鼻唇沟和口周皱纹的长度和角度、黑色素指数（MI）、红斑指数（EI）、经表皮失水率（TEWL）和随访时间。在治疗期间和每次随访时记录副作用：结果：20 名患者顺利完成了研究。第 6 个月时，联合治疗一侧的口周皱纹和鼻唇沟平均长度减少了 11.5%（pwithin within = 0.011），而 MFU 一侧减少了 8.3%（pwithin = 0.012）和 3.8%（pwithin = 0.02）。与单纯的 MFU 治疗相比，联合治疗对鼻唇沟角度（从 28.8 ± 3.4° 到 32.7 ± 5.0°）和口周皱纹角度（从 39.3 ± 5.0° 到 43.7 ± 5.1°）也有显著改善。此外，在改善MI、EI、TEWL和皮肤弹性方面，联合治疗比MFU治疗更有效（pbetween 结论）：MFU 和 DPL 联合用于面部年轻化治疗是安全有效的。联合治疗在紧致皮肤和改善肤色方面有更好的疗效。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.