Evaluation of copeptin in children after stimulation with clonidine or L-Dopa.

IF 1.3 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Journal of Pediatric Endocrinology & Metabolism Pub Date : 2024-03-12 Print Date: 2024-05-27 DOI:10.1515/jpem-2024-0062

Aristeidis Giannakopoulos, Dimitra Kritikou, Dionisios Chrysis

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引用次数: 0

Abstract

Objectives: Arginine-stimulated serum copeptin has been proposed as a new method to diagnose arginine vasopressin (AVP) deficiency in children and adolescents. Herein we investigated the secretagogic potential of clonidine or L-Dopa on the copeptin serum levels in children.

Methods: Eight stimulation tests (4 with clonidine and 4 with L-Dopa) were performed in eight children (5 boys and 3 girls) with a median age of 6.5 years-old, evaluated for short stature due to possible growth hormone deficiency. Serum copeptin levels were measured at 30, 60, 90, and 120 min after administration of clonidine or L-Dopa.

Results: Copeptin levels in serum did not show any significant change in either test (clonidine or L-Dopa). The values of copeptin levels compared to the baseline value did not deviate more than 5 % in the clonidine arm (p=0.60) or 8 % in the L-Dopa arm (p=0.75) respectively.

Conclusions: Data do not support the use of L-Dopa or clonidine as stimulants for evaluating AVP relating disorders in clinical pediatric practice.

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评估氯尼丁或左旋多巴刺激后儿童体内的 copeptin。

目的：精氨酸刺激血清 copeptin 被认为是诊断儿童和青少年精氨酸加压素（AVP）缺乏症的一种新方法。在此，我们研究了氯尼丁或左旋多巴对儿童血清中 copeptin 水平的促泌潜力：方法：我们对 8 名中位数年龄为 6.5 岁的儿童（5 名男孩和 3 名女孩）进行了 8 次刺激试验（4 次使用氯尼丁，4 次使用左旋多巴），评估他们是否因生长激素缺乏而导致身材矮小。在服用氯尼地定或左旋多巴后的 30、60、90 和 120 分钟测量血清中的 copeptin 水平：结果：在两种试验（氯尼丁或左旋多巴）中，血清中的桡肽素水平均无明显变化。与基线值相比，氯尼替丁组和左旋多巴组的桡肽素水平偏差分别不超过5%（P=0.60）和8%（P=0.75）：数据不支持在儿科临床实践中使用左旋多巴或氯尼丁作为兴奋剂来评估与 AVP 相关的疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pediatric Endocrinology & Metabolism 医学-内分泌学与代谢

CiteScore

2.70

自引率

7.10%

发文量

176

审稿时长

3-6 weeks

期刊介绍： The aim of the Journal of Pediatric Endocrinology and Metabolism (JPEM) is to diffuse speedily new medical information by publishing clinical investigations in pediatric endocrinology and basic research from all over the world. JPEM is the only international journal dedicated exclusively to endocrinology in the neonatal, pediatric and adolescent age groups. JPEM is a high-quality journal dedicated to pediatric endocrinology in its broadest sense, which is needed at this time of rapid expansion of the field of endocrinology. JPEM publishes Reviews, Original Research, Case Reports, Short Communications and Letters to the Editor (including comments on published papers),. JPEM publishes supplements of proceedings and abstracts of pediatric endocrinology and diabetes society meetings.