Early Atherosclerosis and Conduction Defect in a Rare Case of Dunnigan Type Familial Partial Lipodystrophy.

Fatih Erkam Olgun, Ekrem Güler, Muhammed Furkan Çeleğen, Bora Demirçelik, Fethi Kılıçaslan, Bilal Boztosun
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Abstract

A 45-year-old female patient was admitted to the emergency department with syncope. Her medical history revealed a diagnosis of Familial Partial Lipodystrophy 2 (FPLD2). The patient's electrocardiogram showed a complete atrioventricular (A-V) block, and she had a history of insulin-dependent diabetes mellitus and coronary artery bypass surgery. A severe stenosis was observed in the aortic right coronary artery saphenous vein graft during coronary angiography, which was successfully revascularized. Subsequently, due to persistant syncope attacks, a permanent pacemaker was implanted after an electrophysiological study. This case highlights that serious cardiac conduction defects in patients with FPLD2 may not only be related to coronary artery disease but can also present as direct conduction defects.

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邓尼根型家族性部分脂肪营养不良罕见病例中的早期动脉粥样硬化和传导缺陷。
急诊科收治了一名晕厥的 45 岁女性患者。她的病史显示她被诊断患有家族性部分脂肪营养不良症2(FPLD2)。患者的心电图显示完全性房室(A-V)传导阻滞,并有胰岛素依赖型糖尿病和冠状动脉搭桥手术史。冠状动脉造影时发现主动脉右冠状动脉隐静脉移植物严重狭窄,并成功进行了血管重建。随后,由于晕厥持续发作,经电生理检查后植入了永久起搏器。本病例强调,FPLD2 患者严重的心脏传导缺陷可能不仅与冠状动脉疾病有关,也可能表现为直接传导缺陷。
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