The potential use of nanozyme in aging and age‐related diseases

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-03-11 DOI:10.1007/s10522-024-10095-w
Amirsasan Gorgzadeh, Paria Arab Amiri, Saman Yasamineh, Basim Kareem Naser, Khairia abdulrahman abdulallah
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Abstract

The effects of an increasingly elderly population are among the most far-reaching in 21st-century society. The growing healthcare expense is mainly attributable to the increased incidence of chronic illnesses that accompany longer life expectancies. Different ideas have been put up to explain aging, but it is widely accepted that oxidative damage to proteins, lipids, and nucleic acids contributes to the aging process. Increases in life expectancy in all contemporary industrialized cultures are accompanied by sharp increases in the prevalence of age-related diseases such as cardiovascular and neurological conditions, type 2 diabetes, osteoporosis, and cancer. Therefore, academic and public health authorities should prioritize the development of therapies to increase health span. Nanozyme (NZ)-like activity in nanomaterials has been identified as promising anti-aging nanomedicines. More than that, nanomaterials displaying catalytic activities have evolved as artificial enzymes with high structural stability, variable catalytic activity, and functional diversity for use in a wide range of biological settings, including those dealing with age-related disorders. Due to their inherent enzyme-mimicking qualities, enzymes have attracted significant interest in treating diseases associated with reactive oxygen species (ROS). The effects of NZs on aging and age-related disorders are summarized in this article. Finally, prospects and threats to enzyme research and use in aging and age-related disorders are offered.

Graphical Abstract

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纳米酶在衰老和老年相关疾病中的潜在用途
老年人口日益增多对 21 世纪社会的影响最为深远。医疗费用不断增长的主要原因是,随着预期寿命的延长,慢性病的发病率也在增加。人们提出了不同的观点来解释衰老,但普遍认为蛋白质、脂类和核酸的氧化损伤是衰老过程的原因。在所有当代工业化文化中,预期寿命延长的同时,与年龄有关的疾病,如心血管和神经系统疾病、2 型糖尿病、骨质疏松症和癌症的发病率也急剧上升。因此,学术界和公共卫生部门应优先开发延长健康寿命的疗法。纳米材料中的纳米酶(NZ)类活性已被确认为有前途的抗衰老纳米药物。不仅如此,具有催化活性的纳米材料已发展成为具有高结构稳定性、可变催化活性和功能多样性的人工酶,可用于各种生物环境,包括与年龄有关的疾病。由于具有模仿酶的固有特性,酶在治疗与活性氧(ROS)有关的疾病方面引起了极大的兴趣。本文概述了 NZs 对衰老和老年相关疾病的影响。最后,提出了在衰老和与年龄有关的疾病中研究和使用酶的前景和威胁。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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