Longitudinal Study on Changes of Cancer-Related Fatigue in Elderly Patients with Postoperative Chemotherapy for Non-Small Cell Lung Cancer.

IF 0.9 4区医学 Q3 SURGERY Annali italiani di chirurgia Pub Date : 2024-01-01

Tingting Wang, Yi Wang, Yiqing Luo, Hui Chen

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引用次数: 0

Abstract

Background: Cancer-related fatigue (CRF) stands out as one of the most prevalent subjective adverse reactions experienced by patients following chemotherapy, often resulting in unfavorable symptoms for elderly non-small cell lung cancer (NSCLC) patients during chemotherapy. Hence, the aim of this study was to explore the fluctuations in CRF levels among elderly NSCLC patients undergoing chemotherapy.

Methods: This retrospective study involved 400 elderly patients diagnosed with NSCLC. Standardized guidelines were employed to direct patient care following lung cancer surgery (T0), subsequent to the first (T1), second (T2), third (T3), and fourth (T4) cycles of chemotherapy. At various intervals, all patients underwent assessments utilizing the Piper Fatigue Scale, Karnofsky Performance Status (KPS) Scale, Pittsburgh Sleep Quality Index (PSQI) Scale, and Connor-Davidson Resilience Scale. Additionally, serum levels of IL-6 and TNF-α were quantified using enzyme-linked immunosorbent assay (ELISA).

Results: Throughout the treatment regimen, patients exhibited a declining trend in CRF, CD-RISC, and KPS scores (p < 0.05, T0 vs T4), whereas the PSQI score demonstrated a notable increase (p < 0.05, T0 vs T4). Furthermore, ELISA results revealed that as treatment advanced, the average levels of inflammatory markers interleukin 6 (IL-6) and tumor necrosis factor (TNF)-α during the T4 period significantly decreased compared to those at T0 (p < 0.05).

Conclusion: As the number of chemotherapy treatments for elderly NSCLC patients increased, the severity of CRF and the manifestations of sleep disorders were escalated. Additionally, physical function, psychological resilience, as well as IL-6 and TNF-α levels, exhibited a downward trend.

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非小细胞肺癌术后化疗老年患者癌症相关疲劳变化的纵向研究

背景：癌症相关疲劳（CRF）是化疗后患者最常见的主观不良反应之一，往往导致老年非小细胞肺癌（NSCLC）患者在化疗期间出现不良症状。因此，本研究旨在探讨接受化疗的老年非小细胞肺癌患者CRF水平的波动情况：这项回顾性研究涉及 400 名确诊为 NSCLC 的老年患者。在肺癌手术后（T0）、第一个化疗周期（T1）、第二个化疗周期（T2）、第三个化疗周期（T3）和第四个化疗周期（T4）之后，采用标准化指南指导患者护理。在不同的时间间隔，所有患者都接受了皮珀疲劳量表、卡诺夫斯基表现状态（KPS）量表、匹兹堡睡眠质量指数（PSQI）量表和康纳-戴维森复原力量表的评估。此外，还使用酶联免疫吸附试验（ELISA）对血清中的 IL-6 和 TNF-α 水平进行了量化：结果：在整个治疗过程中，患者的 CRF、CD-RISC 和 KPS 评分均呈下降趋势（P < 0.05，T0 vs T4），而 PSQI 评分则明显上升（P < 0.05，T0 vs T4）。此外，酶联免疫吸附试验结果显示，随着治疗的进展，白细胞介素6（IL-6）和肿瘤坏死因子（TNF）-α的平均水平在T4期间较T0期间显著下降（P < 0.05）：结论：随着老年 NSCLC 患者化疗次数的增加，CRF 的严重程度和睡眠障碍的表现也随之增加。结论：随着老年 NSCLC 患者化疗次数的增加，CRF 的严重程度和睡眠障碍的表现也随之增加，此外，患者的身体功能、心理适应能力以及 IL-6 和 TNF-α 水平均呈下降趋势。

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来源期刊

Annali italiani di chirurgia 医学-外科

CiteScore

0.90

自引率

12.50%

发文量

116

审稿时长

>12 weeks

期刊介绍： Annali Italiani di Chirurgia is a bimonthly journal and covers all aspects of surgery:elective, emergency and experimental surgery, as well as problems involving technology, teaching, organization and forensic medicine. The articles are published in Italian or English, though English is preferred because it facilitates the international diffusion of the journal (v.Guidelines for Authors and Norme per gli Autori). The articles published are divided into three main sections:editorials, original articles, and case reports and innovations.