Prospects for the Application of Transplantation With Human Amniotic Membrane Epithelial Stem Cells in Systemic Lupus Erythematosus.

IF 3.2 4区医学 Q3 CELL & TISSUE ENGINEERING Cell Transplantation Pub Date : 2024-01-01 DOI:10.1177/09636897241236586

Liping Xu, Qiaoding Dai, Yan Zhang, Na Lin, Lina Ji, Xinwei Song

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Abstract

Systemic lupus erythematosus (SLE) is a multi-organ and systemic autoimmune disease characterized by an imbalance of humoral and cellular immunity. The efficacy and side effects of traditional glucocorticoid and immunosuppressant therapy remain controversial. Recent studies have revealed abnormalities in mesenchymal stem cells (MSCs) in SLE, leading to the application of bone marrow-derived MSCs (BM-MSCs) transplantation technique for SLE treatment. However, autologous transplantation using BM-MSCs from SLE patients has shown suboptimal efficacy due to their dysfunction, while allogeneic mesenchymal stem cell transplantation (MSCT) still faces challenges, such as donor degeneration, genetic instability, and immune rejection. Therefore, exploring new sources of stem cells is crucial for overcoming these limitations in clinical applications. Human amniotic epithelial stem cells (hAESCs), derived from the eighth-day blastocyst, possess strong characteristics including good differentiation potential, immune tolerance with low antigen-presenting ability, and unique immune properties. Hence, hAESCs hold great promise for the treatment of not only SLE but also other autoimmune diseases.

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人羊膜上皮干细胞移植在系统性红斑狼疮中的应用前景。

系统性红斑狼疮（SLE）是一种以体液免疫和细胞免疫失衡为特征的多器官、全身性自身免疫性疾病。传统的糖皮质激素和免疫抑制剂疗法的疗效和副作用仍存在争议。最近的研究发现，间充质干细胞（MSCs）在系统性红斑狼疮中存在异常，因此将骨髓间充质干细胞（BM-MSCs）移植技术应用于系统性红斑狼疮的治疗。然而，使用系统性红斑狼疮患者的骨髓间充质干细胞进行自体移植因其功能障碍而疗效不佳，而异体间充质干细胞移植（MSCT）仍面临供体退化、遗传不稳定和免疫排斥等挑战。因此，探索新的干细胞来源对于克服临床应用中的这些限制至关重要。人羊膜上皮干细胞（hAESCs）来自第八天的囊胚，具有良好的分化潜能、低抗原呈递能力的免疫耐受性和独特的免疫特性。因此，hAESCs 在治疗系统性红斑狼疮和其他自身免疫性疾病方面大有可为。

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来源期刊

Cell Transplantation 生物-细胞与组织工程

CiteScore

6.00

自引率

3.00%

发文量

审稿时长

6 months

期刊介绍： Cell Transplantation, The Regenerative Medicine Journal is an open access, peer reviewed journal that is published 12 times annually. Cell Transplantation is a multi-disciplinary forum for publication of articles on cell transplantation and its applications to human diseases. Articles focus on a myriad of topics including the physiological, medical, pre-clinical, tissue engineering, stem cell, and device-oriented aspects of the nervous, endocrine, cardiovascular, and endothelial systems, as well as genetically engineered cells. Cell Transplantation also reports on relevant technological advances, clinical studies, and regulatory considerations related to the implantation of cells into the body in order to provide complete coverage of the field.