Regulating Triplet Excitons of Organic Luminophores for Promoted Bioimaging.

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current medicinal chemistry Pub Date : 2024-03-11 DOI:10.2174/0109298673301552240305064259
Zhipeng Zhao, Rui Du, Xiaodi Feng, Zhengshuo Wang, Tianjie Wang, Zongzhao Xie, Hua Yuan, Yeqiang Tan, Hanlin Ou
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Abstract

Afterglow materials with organic room temperature phosphorescence (RTP) or thermally activated delayed fluorescence (TADF) exhibit significant potential in biological imaging due to their long lifetime. By utilizing time-resolved technology, interference from biological tissue fluorescence can be mitigated, enabling high signal-- to-background ratio imaging. Despite the continued emergence of individual reports on RTP or TADF in recent years, comprehensive reviews addressing these two materials are rare. Therefore, this review aims to provide a comprehensive overview of several typical molecular designs for organic RTP and TADF materials. It also explores the primary methods through which triplet excitons resist quenching by water and oxygen. Furthermore, we analyze the principal challenges faced by afterglow materials and discuss key directions for future research with the hope of inspiring developments in afterglow imaging.

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调节有机发光体的三重激子,促进生物成像。
具有有机室温磷光(RTP)或热激活延迟荧光(TADF)的余辉材料由于寿命长,在生物成像方面具有巨大潜力。通过利用时间分辨技术,可以减轻生物组织荧光的干扰,实现高信噪比成像。尽管近年来有关 RTP 或 TADF 的个别报道不断涌现,但针对这两种材料的全面综述却很少见。因此,本综述旨在全面概述有机 RTP 和 TADF 材料的几种典型分子设计。它还探讨了三重激子抵抗水和氧淬灭的主要方法。此外,我们还分析了余辉材料所面临的主要挑战,并讨论了未来研究的主要方向,希望能对余辉成像技术的发展有所启发。
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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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