One-Carbon Metabolism Nutrients, Genetic Variation, and Diabetes Mellitus.

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolism Journal Pub Date : 2024-03-01 Epub Date: 2024-03-12 DOI:10.4093/dmj.2023.0272
Jie Zhu, Gunjana Saikia, Xiaotao Zhang, Xiaoxi Shen, Ka Kahe
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Abstract

Diabetes mellitus (DM) affects about 9.3% of the population globally. Hyperhomocysteinemia (HHcy) has been implicated in the pathogenesis of DM, owing to its promotion of oxidative stress, β-cell dysfunction, and insulin resistance. HHcy can result from low status of one-carbon metabolism (OCM) nutrients (e.g., folate, choline, betaine, vitamin B6, B12), which work together to degrade homocysteine by methylation. The etiology of HHcy may also involve genetic variation encoding key enzymes in OCM. This review aimed to provide an overview of the existing literature assessing the link between OCM nutrients status, related genetic factors, and incident DM. We also discussed possible mechanisms underlying the role of OCM in DM development and provided recommendations for future research and practice. Even though the available evidence remains inconsistent, some studies support the potential beneficial effects of intakes or blood levels of OCM nutrients on DM development. Moreover, certain variants in OCM-related genes may influence metabolic handling of methyl-donors and presumably incidental DM. Future studies are warranted to establish the causal inference between OCM and DM and examine the interaction of OCM nutrients and genetic factors with DM development, which will inform the personalized recommendations for OCM nutrients intakes on DM prevention.

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一碳代谢营养素、遗传变异与糖尿病。
全球约有 9.3% 的人患有糖尿病(DM)。高同型半胱氨酸血症(HHcy)与糖尿病的发病机制有关,因为它会促进氧化应激、β 细胞功能障碍和胰岛素抵抗。一碳代谢(OCM)营养素(如叶酸、胆碱、甜菜碱、维生素 B6 和 B12)通过甲基化作用降解同型半胱氨酸。HHcy 的病因还可能涉及编码 OCM 中关键酶的基因变异。本综述旨在概述现有文献,评估 OCM 营养状况、相关遗传因素和糖尿病发病之间的联系。我们还讨论了 OCM 在糖尿病发展中发挥作用的可能机制,并为未来的研究和实践提供了建议。尽管现有的证据仍不一致,但一些研究支持 OCM 营养素的摄入量或血液水平对 DM 的发生有潜在的有益影响。此外,OCM 相关基因中的某些变异可能会影响甲基供体的代谢处理,并可能导致意外的 DM。今后有必要开展研究,以确定 OCM 与 DM 之间的因果推论,并研究 OCM 营养素和遗传因素与 DM 发展之间的相互作用,从而为预防 DM 的 OCM 营养素摄入量的个性化建议提供依据。
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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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