Investigating the relationship between sleep disturbances and white matter hyperintensities in older adults on the Alzheimer's disease spectrum.

IF 4 Q1 CLINICAL NEUROLOGY Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Pub Date : 2024-03-11 eCollection Date: 2024-01-01 DOI:10.1002/dad2.12553

Farooq Kamal, Cassandra Morrison, Mahsa Dadar

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Abstract

Introduction: While studies report that sleep disturbance can have negative effects on brain vasculature, its impact on cerebrovascular diseases such as white matter hyperintensities (WMHs) in beta-amyloid-positive older adults remains unexplored.

Methods: Sleep disturbance, WMH burden, and cognition in normal controls (NCs), and individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD), were examined at baseline and longitudinally. A total of 912 amyloid-positive participants were included (198 NC, 504 MCI, and 210 AD).

Results: Individuals with AD reported more sleep disturbances than NC and MCI participants. Those with sleep disturbances had more WMHs than those without sleep disturbances in the AD group. Mediation analysis revealed an effect of regional WMH burden on the relationship between sleep disturbance and future cognition.

Discussion: These results suggest that WMH burden and sleep disturbance increase from aging to AD. Sleep disturbance decreases cognition through increases in WMH burden. Improved sleep could mitigate the impact of WMH accumulation and cognitive decline.

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研究阿尔茨海默氏症谱系中老年人睡眠障碍与白质高密度之间的关系。

导言：尽管有研究报告称睡眠障碍会对脑血管产生负面影响，但睡眠障碍对脑血管疾病（如β-淀粉样蛋白阳性老年人的白质高密度（WMH））的影响仍未得到探讨：方法：研究人员对正常对照组（NCs）、轻度认知障碍（MCI）和阿尔茨海默病（AD）患者的睡眠障碍、WMH 负荷和认知能力进行了基线和纵向研究。共纳入了912名淀粉样蛋白阳性参与者（198名NC、504名MCI和210名AD）：结果：与 NC 和 MCI 参与者相比，AD 患者报告的睡眠障碍更多。在AD组中，有睡眠障碍者比无睡眠障碍者有更多的WMHs。中介分析显示，区域性WMH负担会影响睡眠障碍与未来认知能力之间的关系：这些结果表明，从衰老到AD，WMH负担和睡眠障碍都会增加。睡眠障碍会通过增加WMH负担降低认知能力。改善睡眠可减轻WMH积累和认知能力下降的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring Medicine-Psychiatry and Mental Health

CiteScore

7.80

自引率

7.50%

发文量

101

审稿时长

8 weeks

期刊介绍： Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.