Successful treatment with granulocyte and monocyte adsorption apheresis for plaque-type skin lesions in patients with psoriatic arthritis.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2024-08-01 Epub Date: 2024-03-12 DOI:10.1111/1744-9987.14118

Mariko Seishima, Hideki Hachiken, Takuma Furukawa, Junichiro Yamamoto

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Abstract

Introduction: Granulocyte and monocyte adsorption apheresis (GMA) is usually performed weekly for refractory skin diseases, such as generalized pustular psoriasis and psoriatic arthritis (PsA).

Methods: Four patients with PsA who were refractory to previous treatments were enrolled. They received five or ten sessions of GMA. We assessed the clinical conditions of each patient and laboratory findings before and after GMA.

Results: GMA was effective in plaque-type skin eruptions in all four patients with PsA. It was also effective in joint symptoms in three patients with PsA with mild symptoms, but was ineffective in one patient with severe joint symptoms.

Conclusion: GMA may be recommended to PsA patients with skin eruptions and mild joint symptoms.

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用粒细胞和单核细胞吸附分离疗法成功治疗银屑病关节炎患者的斑块型皮损。

导言：粒细胞和单核细胞吸附分离术（GMA）通常每周进行一次，用于治疗难治性皮肤病，如泛发性脓疱型银屑病和银屑病关节炎（PsA）：方法：共招募了四名对以往治疗无效的 PsA 患者。他们接受了五次或十次 GMA 治疗。我们评估了每位患者在 GMA 治疗前后的临床状况和实验室检查结果：结果：GMA 对所有四名 PsA 患者的斑块型皮肤糜烂均有效。结果：GMA 对四名 PsA 患者的斑块型皮肤糜烂均有效，对三名症状轻微的 PsA 患者的关节症状也有效，但对一名关节症状严重的患者无效：结论：GMA可推荐给有皮肤糜烂和轻度关节症状的PsA患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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