Synthesis of α-ketothioamides with elemental sulfur under solvent-free conditions in a mixer mill†

Chandan Chittapriya Sahu, Sourav Biswas, Renè Hommelsheim and Carsten Bolm
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Abstract

A mechanochemical base-mediated synthesis of α-ketothioamide from readily available acetophenone derivatives is developed. The reaction is metal-free, solventless, and proceeds in a short reaction time. Importantly, the products differ from those formed under standard solution-based protocols.

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在无溶剂条件下用元素硫在混合磨中合成 α-硫代酮酰胺†。
本研究开发了一种以容易获得的苯乙酮衍生物为原料的机械化学碱介导的 α-硫代酮酰胺合成方法。该反应不含金属,无溶剂,反应时间短。重要的是,该反应生成的产物与标准溶液法生成的产物不同。
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