Radical Copolymerization of p-Aminophenylcyclopropylmethyl Methacrylate with Methyl Methacrylate

Abstract

p-Aminophenylcyclopropylmethyl methacrylate monomer was prepared, and its free-radical copolymerization with methyl methacrylate was performed. The monomer and copolymer were characterized by IR and NMR spectroscopy. The relative activity constants of the monomer were determined, and the monomer activity and polarity were calculated by the Alfrey–Price method. The copolymerization constant of p-aminophenylcyclopropylmethyl methacrylate exceeds that of methyl methacrylate; therefore, the copolymer is enriched in units of specifically this comonomer. The copolymers based on p-aminophenylcyclopropylmethyl methacrylate exhibit high biological activity toward Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and toward Candida albicans fungi.