The Intake of Cruciferous Vegetables and the Risk of Ovarian Cancer: A Systematic Review and Dose-Response Meta-Analysis.

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY Gynecologic and Obstetric Investigation Pub Date : 2024-01-01 Epub Date: 2024-03-13 DOI:10.1159/000537692

Meiqiong Li, Jiaye Long, Miyang Yang, Yingrong Pang, Baoxiang Chen, Hong Li

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Abstract

Introduction: The link between cruciferous vegetables (CVs) and ovarian cancer (OC) is still uncertain. This meta-analysis is intended to investigate the association between CV consumption and the risk of OC, as well as to conduct a dose-response analysis to determine the degree of correlation between them.

Methods: We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases between database creation and October 2023. The present meta-analysis has been duly registered and assigned the registration number CRD42023470299. This study followed the PRISMA guidelines. The statistical analysis was performed using Stata 14.0 software.

Results: There were a total of 7 cohort studies and 7 case-control studies with 7,269 cases and 742,952 subjects. The combined relative risk (RR) of the highest intake of CVs was 0.90 (95% confidence intervals [CIs]: 0.84-0.96; I2 = 54.7%; p = 0.007) compared to the lowest intake of CVs. The odds ratio (OR) was 0.97 (95% CIs: 0.86-1.08; p = 0.192) for cohort studies, and the RR was 0.79 (95% CIs: 0.67-0.91; p = 0.167) for case-control studies. The intake of CVs and the risk of OC were linearly correlated. Adding 15 g of CVs to the diet each day decreased the likelihood of developing OC by almost 4% (RR = 0.963, 95% CIs: 0.905-1.025; p = 0.235).

Conclusions: Consumption of CVs may be linked to a lower risk of OC.

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十字花科蔬菜的摄入量与卵巢癌风险：系统综述和剂量反应荟萃分析。

导言：十字花科蔬菜（CVs）与卵巢癌（OC）之间的关系仍不确定。这项荟萃分析旨在研究十字花科蔬菜的食用量与卵巢癌风险之间的关系，并进行剂量-反应分析，以确定两者之间的相关程度：我们系统地检索了从数据库创建到 2023 年 10 月期间的 PubMed、Web of Science、Embase 和 Cochrane Library 数据库。本荟萃分析已正式注册，注册号为 CRD42023470299。本研究遵循 PRISMA 指南。统计分析使用 Stata 14.0 软件进行：共有 7 项队列研究和 7 项病例对照研究，研究对象分别为 7,269 例和 742,952 例。与CV摄入量最低的研究相比，CV摄入量最高的研究的综合相对风险（RR）为0.90（95%置信区间[CIs]：0.84-0.96；I2=54.7%；P=0.007）。病例对照研究的几率比（OR）为 0.97（95% CIs：0.86-1.08；P=0.192），队列研究的 RR 为 0.79（95% CIs：0.67-0.91；P=0.167）。CV 摄入量与 OC 风险呈线性相关。每天在饮食中添加 15 克 CVs 可使罹患 OC 的可能性降低近 4%（RR=0.963，95% CIs：0.905-1.025；P=0.235）：结论：摄入碳氢化合物可能与降低罹患卵巢癌的风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic and Obstetric Investigation 医学-妇产科学

CiteScore

4.20

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal covers the most active and promising areas of current research in gynecology and obstetrics. Invited, well-referenced reviews by noted experts keep readers in touch with the general framework and direction of international study. Original papers report selected experimental and clinical investigations in all fields related to gynecology, obstetrics and reproduction. Short communications are published to allow immediate discussion of new data. The international and interdisciplinary character of this periodical provides an avenue to less accessible sources and to worldwide research for investigators and practitioners.