An investigation of the antimicrobial efficacy of a nonwoven CMC PHMB dressing and the ability of the dressing to absorb wound slough.

IF 1.4 4区医学 Q3 DERMATOLOGY Wounds : a compendium of clinical research and practice Pub Date : 2024-02-01

Cerys Griffiths, Emily Oakes, Daniel Cook, Lynne Salmon, Alex Lawton

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引用次数: 0

Abstract

Objective: To conduct an in vitro investigation into the slough absorption and retention attributes of a gelling fiber dressing composed of CMC fibers and PHMB (Dressing A), and to assess its antimicrobial efficacy under compression.

Materials and methods: Dressing A is indicated for use with secondary dressings or bandaging, and conditions that replicate this compression element were applied. Dressing A was compared with 5 other dressings. Antimicrobial efficacy testing was conducted over a 7-day challenge period.

Results: Dressing A absorbed an average of 33 g/100 cm2 per sample of viscous solution, 28% more than the other dressings tested. A greater than or equal to 6-log reduction of all microorganisms tested was achieved within 168 hours with Dressing A.

Conclusion: The CMC PHMB gelling fiber dressing is able to absorb and retain viscous solutions (simulated slough). The antimicrobial efficacy of the dressing under compression was demonstrated by total eradication of all microorganisms tested.

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研究无纺布 CMC PHMB 敷料的抗菌功效以及敷料吸收伤口淤血的能力。

目的对由 CMC 纤维和 PHMB 组成的胶凝纤维敷料（敷料 A）的蜕皮吸收和保留特性进行体外研究，并评估其在加压情况下的抗菌功效：敷料 A 适用于辅助敷料或绷带，使用条件与这种加压元素相同。敷料 A 与其他 5 种敷料进行了比较。抗菌效果测试为期 7 天：结果：敷料 A 平均吸收了每 100 平方厘米样本 33 克的粘稠溶液，比其他接受测试的敷料高出 28%。敷料 A 在 168 小时内实现了所有测试微生物的减少量大于或等于 6 个菌落：结论：CMC PHMB 胶凝纤维敷料能够吸收和保留粘性溶液（模拟蜕皮）。结论：CMC PHMB 胶凝纤维敷料能够吸收和保留粘稠溶液（模拟蜕皮），通过完全清除所有测试微生物，证明了该敷料在加压条件下的抗菌功效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wounds : a compendium of clinical research and practice 医学-皮肤病学

CiteScore

1.50

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Wounds is the most widely read, peer-reviewed journal focusing on wound care and wound research. The information disseminated to our readers includes valuable research and commentaries on tissue repair and regeneration, biology and biochemistry of wound healing, and clinical management of various wound etiologies. Our multidisciplinary readership consists of dermatologists, general surgeons, plastic surgeons, vascular surgeons, internal medicine/family practitioners, podiatrists, gerontologists, researchers in industry or academia (PhDs), orthopedic surgeons, infectious disease physicians, nurse practitioners, and physician assistants. These practitioners must be well equipped to deal with a myriad of chronic wound conditions affecting their patients including vascular disease, diabetes, obesity, dermatological disorders, and more. Whether dealing with a traumatic wound, a surgical or non-skin wound, a burn injury, or a diabetic foot ulcer, wound care professionals turn to Wounds for the latest in research and practice in this ever-growing field of medicine.