Biphenotypic lung carcinoma with coexpression of TTF-1 and ΔNP63/P40 within most of the same individual cells: a further case confirming poor prognosis and a review of literature.

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2024-02-01 DOI:10.32074/1591-951X-957
Alessandro Marando, Moreno Zagni, Mariachiara Negrelli, Emanuele Valtorta, Calogero Lauricella, Valentina Motta, Silvio Veronese, Giulio Cerea, Laura Giuseppina Giannetta, Gabriele Ciarlo, Diego Signorelli, Elio Gregory Pizzutilo, Emanuela Bonoldi, Giuseppe Pelosi
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引用次数: 0

Abstract

The WHO Classification of Tumors, Thoracic Tumors, 5th edition, has outlined the use of TTF-1 and ΔNP63/P40 to discriminate between adenocarcinoma and squamous cell carcinoma. In 2015, the first description of a rare non-small cell lung carcinoma featuring co-expression of glandular and squamous differentiation within most of the same individual tumor cells was reported on, with ultrastructural and molecular demonstration of such a biphenotypic differentiation. We herein describe an additional case of this rare tumor entity, which is confirmed to be an aggressive neoplasm despite potential targets of therapy.

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在大多数相同的单个细胞中TTF-1和ΔNP63/P40共表达的双型肺癌:又一例证实预后不良的病例及文献综述。
世界卫生组织肿瘤分类--胸部肿瘤》第五版概述了使用TTF-1和ΔNP63/P40来区分腺癌和鳞癌。2015 年,首次报道了一种罕见的非小细胞肺癌,其特点是在大多数相同的单个肿瘤细胞中同时表达腺分化和鳞分化,并在超微结构和分子上证明了这种双型分化。我们在此描述了这一罕见肿瘤实体的另一个病例,该病例被证实是一种侵袭性肿瘤,尽管有潜在的治疗目标。
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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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