Van Dat Doan, Thi Lan Pham, Tuan Anh Nguyen, Van Cuong Bui, Xuan Minh Vu, Thi Lan Huong Nguyen, Thi My Hanh Le, Hai Khoa Le, Thanh Tung Mai, Dai lam Tran
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引用次数: 0
Abstract
In this work, a novel papaya seed-based activated carbon/Fe3O4/AgNPs nanocomposite (MAC/Ag) was prepared via a one-pot in situ approach and used as a versatile peroxidase mimic for colorimetric detection of ascorbic acid (AA). The MAC/Ag nanocomposite exhibited enhanced peroxidase-like activity, catalyzing the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of hydrogen peroxide (H2O2) and yielding colorimetric products. By optimizing the experimental conditions, the MAC/Ag-TMB-H2O2 detection platform displayed outstanding sensitivity towards AA, with an impressively low detection limit of 0.056 µM in the linear range of 25–500 µM. Notably, the platform demonstrated remarkable reusability and stability, maintaining a high level of activity even after numerous reuse cycles. The comprehensive investigation of the underlying mechanism revealed the crucial role of hydroxyl radicals. The successful quantitative analysis of AA in papaya juice verified the applicability of the MAC/Ag-TMB-H2O2 assay. These findings highlight the potential of the MAC/Ag nanocomposite as a reliable and reusable detection nanozyme for AA, offering promising prospects in environmental monitoring, biomedical diagnostics, and pharmaceutical analysis.
期刊介绍:
The journal publishes the following types of papers: (a) original and important research;
(b) authoritative comprehensive reviews or short overviews of topics of current
interest; (c) brief but urgent communications on new significant research; and (d)
commentaries intended to foster the exchange of innovative or provocative ideas, and
to encourage dialogue, amongst researchers working in different cluster
disciplines.