Obesity and mortality in patients with COVID-19: A meta-analysis of prospective studies.

IF 1.3 4区医学 Q4 NUTRITION & DIETETICS Asia Pacific journal of clinical nutrition Pub Date : 2024-03-01 DOI:10.6133/apjcn.202403_33(1).0007

Heram Cho, Yunseo Park, Seung-Kwon Myung

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Abstract

Background and objectives: Previous prospective studies have reported inconsistent findings on the associ-ation between obesity and mortality in patients with COVID-19. This study aimed to investigate the associa-tion between them by using a meta-analysis of prospective studies.

Methods and study design: We searched PubMed and EMBASE to retrieve studies using keywords related to this topic on January 3, 2022. Data were extracted for a random-effects meta-analysis to calculate a pooled odds ratio (OR), relative risk (RR), or hazard ratio (HR) with a 95% confidence interval (CI).

Results: In the meta-analysis of 15 prospective cohort studies, obesity significantly increased the risk of mortality in patients with COVID-19 (OR/RR/HR, 1.52; 95% CI, 1.26 to 1.84; I2 = 90.4%). Most of the included studies were conducted in European (n = 10) and North American (n = 4) countries. In the subgroup meta-analysis by continent, there was a significant association between them in European countries (OR/RR/HR, 1.78; 95% CI, 1.30 to 2.43; I2 = 81.4%). Also, in the subgroup meta-analysis by data source, obesity was significantly associated with the increased mortality in patients with COVID-19 in both population- and hospital-based data.

Conclusions: We found that obesity is associated with the increased risk of mortality in patients of COVID-19.

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肥胖与 COVID-19 患者的死亡率：前瞻性研究的荟萃分析。

背景和目的：以往的前瞻性研究对COVID-19患者肥胖与死亡率之间的关系报道不一。本研究旨在通过对前瞻性研究进行荟萃分析，探讨两者之间的关系：我们检索了PubMed和EMBASE，使用2022年1月3日与该主题相关的关键词检索研究。提取数据进行随机效应荟萃分析，以计算汇总的几率比（OR）、相对风险（RR）或危险比（HR）及95%置信区间（CI）：在对 15 项前瞻性队列研究进行的荟萃分析中，肥胖会显著增加 COVID-19 患者的死亡风险（OR/RR/HR，1.52；95% CI，1.26 至 1.84；I2 = 90.4%）。纳入的研究大多在欧洲（10 项）和北美（4 项）国家进行。在按大洲进行的分组荟萃分析中，欧洲国家的研究结果与北美国家的研究结果有显著关联（OR/RR/HR，1.78；95% CI，1.30 至 2.43；I2 = 81.4%）。此外，在按数据来源进行的亚组荟萃分析中，在基于人口和医院的数据中，肥胖与COVID-19患者死亡率升高有显著相关性：我们发现，肥胖与 COVID-19 患者死亡风险的增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific journal of clinical nutrition 医学-营养学

CiteScore

2.50

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board