Combining Surgery, Radiotherapy, and Topical Chemotherapy to Prevent Primary Orbital Exenteration for Atypical Caruncular Melanoma: A Case Report.

IF 0.5 Q4 OPHTHALMOLOGY Case Reports in Ophthalmology Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI:10.1159/000536590

Cédric De Landsheer, Valentien Merlevede, Celine Jacobs, Jo Van Dorpe, Julie De Zaeytijd, Virginie G S Ninclaus, Dimitri Roels

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Abstract

Introduction: This case report demonstrates the possibility of successful eye and vision-sparing therapy for caruncular melanoma.

Case presentation: We present an atypical presentation of a caruncular melanoma. After excisional biopsy, residual flat conjunctival melanosis resolved using topical chemotherapy (5-fluorouracil), which was well tolerated. Relapse of the melanoma was treated with external beam radiotherapy, but the tumor grew despite treatment. Eighteen months after complete excision of the relapsed melanoma, the patient remains tumor-free while the eye and its function remain preserved.

Conclusion: This case report suggests that aggressive eye-sparing therapy for caruncular melanoma combining surgery, adjuvant topical chemotherapy, and external beam radiotherapy, can be an alternative for primary orbital exenteration.

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结合手术、放疗和局部化疗，防止非典型眼眶黑色素瘤的原发性眼眶扩张：病例报告。

导言：本病例报告展示了对眼眶黑色素瘤进行保眼和保视治疗的可能性：本病例报告展示了成功治疗眼眶黑色素瘤和保护视力的可能性：我们介绍了一例非典型的眼球黑色素瘤。切除活检后，残留的扁平结膜黑色素瘤通过局部化疗（5-氟尿嘧啶）得到缓解，患者耐受良好。黑色素瘤复发后，患者接受了体外放射治疗，但治疗后肿瘤仍在生长。在完全切除复发的黑色素瘤 18 个月后，患者仍然没有肿瘤，眼球及其功能也得以保留：本病例报告表明，结合手术、辅助局部化疗和体外放射治疗的积极保眼疗法可替代原发性眼眶外切术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.