Secondary organizing pneumonia associated with protracted COVID: A case series

IF 2.9 4区医学 Q2 INFECTIOUS DISEASES Infectious diseases now Pub Date : 2024-03-15 DOI:10.1016/j.idnow.2024.104888

P-Y. Sansen , E. Coche , P. Hainaut , A. Froidure , A. Scohy , B. Ghaye , L. Belkhir , J. De Greef

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Abstract

Objectives

Immunocompromised B-cell-depleted patients are at risk of developing protracted COVID-19, a clinical syndrome characterized by prolonged viral shedding and respiratory symptoms that can lead to hypoxemic pneumonia. Our aim is to describe this unusual condition and its treatment.

Patients and methods

This monocentric retrospective study reports six cases of severe organizing pneumonia that developed during the clinical course of protracted COVID-19.

Results

All patients developed organizing pneumonia (OP) in the setting of protracted COVID. Clinical improvement was obtained after several treatment lines including specific antiviral agents and occurred simultaneously with control of the viral load.

Conclusion

As it was the most frequent presentation of protracted COVID-19 in our survey, we believe that this specific form of organizing pneumonia warrants increased awareness. Furthermore, specific antiviral therapy seems to control this condition.

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与长期 COVID 相关的继发性组织化肺炎：一个病例系列。

目的：免疫功能低下的 B 细胞耗竭患者有可能患上慢性 COVID-19 综合征，这种临床综合征的特点是病毒长期脱落和呼吸道症状，可导致低氧性肺炎。我们的目的是描述这种不寻常的情况及其治疗方法：这项单中心回顾性研究报告了 6 例在长期 COVID-19 临床过程中出现的严重组织化肺炎病例：结果：所有患者均在COVID-19病程延长的情况下发生了组织化肺炎（OP）。经过包括特异性抗病毒药物在内的多个治疗方案后，临床症状得到改善，病毒载量也同时得到控制：结论：在我们的调查中，组织性肺炎是 COVID-19 中最常见的病症，因此我们认为这种特殊形式的组织性肺炎值得引起更多关注。此外，特异性抗病毒治疗似乎也能控制病情。

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