Factors associated with Entamoeba histolytica proctocolitis in men who have sex with men: a systematic review

Abstract

Objective Entamoeba histolytica is parasitic infection that can cause a proctocolitis (amoebiasis) and extraintestinal sequelae (eg, liver abscess) and can be sexually transmitted in men who have sex with men (MSM). We aimed to identify factors associated with E. histolytica in MSM to provide insight for future control strategies. Design/methods We searched MEDLINE, Embase, CINAHL and Web of Science Core Collections for manuscripts published up to November 2022. One author screened abstracts; two authors independently conducted a full-text review. We included manuscripts that contained primary data on factors associated with transmission in MSM. Quality and risk of bias were assessed independently by two authors using the Joanna Briggs Institute critical appraisal tools. We used the nine-point synthesis method to synthesise narrative data. Results Nine manuscripts consisting of 832 individuals with E. histolytica were included; six cross-sectional studies, two case-control studies and one cohort study. E. histolytica in MSM was associated with: increasing age, transmission in warm seasons, lower educational achievement, concurrent sexually transmitted infection (STI) ( Treponema pallidum , Neisseria gonorrhoeae , Chlamydia trachomatis ), hepatitis B core antibody positivity, hepatitis C antibody positivity, concurrent sexually transmitted enteric infection ( Shigella spp, Giardia duodenalis ), having a previous STI ( T. pallidum, N. gonorrhoeae ), oral-anal sex, exclusively/majority receptive anal sex and having an increased number of sexual partners. Conclusion This review has highlighted some important demographic, biological and behavioural factors associated with E. histolytica in MSM which can inform future clinical guidelines and public health control strategies. PROSPERO registration number CRD42022366168. Data sharing not applicable to this article as no data sets were generated or analysed during the current study.