Recent advances in the biosynthesis and industrial biotechnology of Gamma-amino butyric acid

IF 4.3 3区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Bioresources and Bioprocessing Pub Date : 2024-03-16 DOI:10.1186/s40643-024-00747-7

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Abstract

GABA (Gamma-aminobutyric acid), a crucial neurotransmitter in the central nervous system, has gained significant attention in recent years due to its extensive benefits for human health. The review focused on recent advances in the biosynthesis and production of GABA. To begin with, the investigation evaluates GABA-producing strains and metabolic pathways, focusing on microbial sources such as Lactic Acid Bacteria, Escherichia coli, and Corynebacterium glutamicum. The metabolic pathways of GABA are elaborated upon, including the GABA shunt and critical enzymes involved in its synthesis. Next, strategies to enhance microbial GABA production are discussed, including optimization of fermentation factors, different fermentation methods such as co-culture strategy and two-step fermentation, and modification of the GABA metabolic pathway. The review also explores methods for determining glutamate (Glu) and GABA levels, emphasizing the importance of accurate quantification. Furthermore, a comprehensive market analysis and prospects are provided, highlighting current trends, potential applications, and challenges in the GABA industry. Overall, this review serves as a valuable resource for researchers and industrialists working on GABA advancements, focusing on its efficient synthesis processes and various applications, and providing novel ideas and approaches to improve GABA yield and quality.

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γ-氨基丁酸的生物合成和工业生物技术的最新进展

摘要 GABA（γ-氨基丁酸）是中枢神经系统中的一种重要神经递质，近年来因其对人类健康的广泛益处而备受关注。本综述侧重于 GABA 的生物合成和生产方面的最新进展。首先，调查评估了 GABA 的生产菌株和代谢途径，重点是乳酸菌、大肠杆菌和谷氨酸棒杆菌等微生物来源。详细阐述了 GABA 的代谢途径，包括 GABA 分流和参与其合成的关键酶。接下来讨论了提高微生物 GABA 产量的策略，包括优化发酵因素、不同的发酵方法（如共培养策略和两步发酵法）以及 GABA 代谢途径的改变。综述还探讨了测定谷氨酸（Glu）和 GABA 水平的方法，强调了精确定量的重要性。此外，报告还提供了全面的市场分析和前景展望，重点介绍了 GABA 行业的当前趋势、潜在应用和挑战。总之，本综述是从事 GABA 研究的研究人员和工业家的宝贵资源，重点介绍了 GABA 的高效合成工艺和各种应用，并提供了提高 GABA 产量和质量的新思路和新方法。图表摘要

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来源期刊

Bioresources and Bioprocessing BIOTECHNOLOGY & APPLIED MICROBIOLOGY-

CiteScore

7.20

自引率

8.70%

发文量

118

审稿时长

13 weeks

期刊介绍： Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen. BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal, BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes. BIOB publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including: -Biochemical and microbiological engineering -Biocatalysis and biotransformation -Biosynthesis and metabolic engineering -Bioprocess and biosystems engineering -Bioenergy and biorefinery -Cell culture and biomedical engineering -Food, agricultural and marine biotechnology -Bioseparation and biopurification engineering -Bioremediation and environmental biotechnology