Measles-specific antibodies loss after a single dose of MMR vaccine in children with oligo-articular JIA on methotrexate treatment: a single-center case-controlled study.

IF 3.2 3区 医学 Q2 RHEUMATOLOGY Rheumatology International Pub Date : 2024-12-01 Epub Date: 2024-03-18 DOI:10.1007/s00296-024-05563-y
Ioannis Kopsidas, Lida Mentesidou, Angeliki Syggelou, Maria Papadimitriou, Minos Matsas, Lydia Kossiva, Despoina N Maritsi
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Abstract

Novel treatments have revolutionized the care and outcome of patients with juvenile idiopathic arthritis (JIA). Patients with rheumatic diseases are susceptible to infections, including vaccine preventable ones, due to waning immunity, failing immune system and immunosuppressive treatment received. However, data regarding long-term immunological memory and response to specific vaccines are limited. Assessment of the impact of methotrexate (MTX) treatment on measles-specific-IgG titers, in children with oligo-JIA previously vaccinated with Measles Mumps Rubella (MMR) vaccine (1 dose); by evaluating the persistence of antibodies produced after measles vaccination while on immunomodulating treatment at 0, 12 and 24 months. Single-center controlled study including 54 oligo-JIA patients and 26 healthy controls. Seroprotection rates and measles-specific-IgG titers were measured by ELISA and were expressed as GMCs (Geometric Mean Concentrations).The two groups had similar demographic characteristics, vaccination history and immunization status. Seroprotection rates were adequate for both groups. Nonetheless, measles GMCs were significantly lower in the oligo-JIA compared to the control group at one (p = 0.039) and two years' follow-up (p = 0.021). Children with oligo-JIA on MTX treatment appeared to have lower measles-specific-IgG titers. Further studies are required to assess the long-term immunity conveyed by immunizations given at an early stage in children with rheumatic diseases on synthetic Disease Modifying Antirheumatic Drugs (sDMARDs) and to assess the need for booster doses to subjects at risk.

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接受甲氨蝶呤治疗的少关节型 JIA 儿童接种一剂麻风腮疫苗后麻疹特异性抗体丢失:一项单中心病例对照研究。
新疗法彻底改变了对幼年特发性关节炎(JIA)患者的护理和治疗效果。由于免疫力下降、免疫系统衰竭和接受免疫抑制治疗,风湿病患者很容易受到感染,包括可通过疫苗预防的感染。然而,有关长期免疫记忆和对特定疫苗反应的数据却很有限。评估甲氨蝶呤(MTX)治疗对曾接种过麻疹腮腺炎风疹(MMR)疫苗(1剂)的少症强直性脊柱炎患儿的麻疹特异性 IgG 滴度的影响;在 0、12 和 24 个月接受免疫调节治疗期间,评估接种麻疹疫苗后产生的抗体的持续性。单中心对照研究包括 54 名少精子症患者和 26 名健康对照者。血清保护率和麻疹特异性 IgG 滴度通过酶联免疫吸附试验(ELISA)测定,以 GMCs(几何平均浓度)表示。两组的血清保护率相当。然而,在一年(p = 0.039)和两年(p = 0.021)的随访中,少儿 JIA 患儿的麻疹 GMCs 明显低于对照组。接受MTX治疗的少JIA患儿的麻疹特异性IgG滴度似乎较低。需要开展进一步的研究,以评估使用合成疾病修饰抗风湿药(sDMARDs)的风湿病患儿在早期接受免疫接种所产生的长期免疫力,并评估是否有必要为高危人群加强免疫接种。
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来源期刊
Rheumatology International
Rheumatology International 医学-风湿病学
CiteScore
7.30
自引率
5.00%
发文量
191
审稿时长
16. months
期刊介绍: RHEUMATOLOGY INTERNATIONAL is an independent journal reflecting world-wide progress in the research, diagnosis and treatment of the various rheumatic diseases. It is designed to serve researchers and clinicians in the field of rheumatology. RHEUMATOLOGY INTERNATIONAL will cover all modern trends in clinical research as well as in the management of rheumatic diseases. Special emphasis will be given to public health issues related to rheumatic diseases, applying rheumatology research to clinical practice, epidemiology of rheumatic diseases, diagnostic tests for rheumatic diseases, patient reported outcomes (PROs) in rheumatology and evidence on education of rheumatology. Contributions to these topics will appear in the form of original publications, short communications, editorials, and reviews. "Letters to the editor" will be welcome as an enhancement to discussion. Basic science research, including in vitro or animal studies, is discouraged to submit, as we will only review studies on humans with an epidemological or clinical perspective. Case reports without a proper review of the literatura (Case-based Reviews) will not be published. Every effort will be made to ensure speed of publication while maintaining a high standard of contents and production. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.
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