The Influence of Increased Concentrations of Brain Natriuretic Peptide on the Level of Hemodynamic Reactions in Individuals Living and Working in the European North and the Arctic of the Russian Federation

Abstract

The authors examined 111 practically healthy individuals (66 women and 45 men aged 46–55 years) living and working in the Spitsbergen archipelago as well as in Murmansk oblast. The comparison group included 118 practically healthy people (59 women and 59 men, 46–55 years old) born and living in Arkhangelsk oblast. The hemogram of peripheral venous blood, the content of lymphocytes with the phenotypes CD3+, CD4+, CD8+, CD10+, CD16+, CD19+, CD23+, CD25+, and CD71+ were studied using indirect immunoperoxidase reaction and flow cytometry; concentrations of brain natriuretic peptide Nt-pro-BNP, endothelin-1, total NO, endogenous NO₂, nitrate NO₃, cortisol, norepinephrine, adrenaline were studied using enzyme-linked immunosorbent assay. It has been established that individuals living in the Arctic and territories equated to the regions of the Far North have a higher concentration of Nt-pro-BNP in the venous peripheral blood. Elevated blood concentrations of Nt-pro-BNP are associated with higher levels of norepinephrine and cortisol against the background of less pronounced concentrations of adrenaline and endothelin-1 as well as redistribution of lymphocytes and monocytes from the circulating pool to the marginal pool.