Modernization of the Synthesis and Anti-Inflammatory Activity of 4,10-di(2-Ethoxyacetyl)-2,6,8,12-Tetraacetyl-2,4,6,8,10,12-Hexaazaisowurtzitane – An Innovative Non-Narcotic Analgesic
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Abstract
A modified method for the synthesis of a promising non-narcotic analgesic agent of the hexaazaisowurtzitane class with pronounced anti-inflammatory activity is described. Methods for reducing the cost of the target substance are considered. The physicochemical characteristics are described. The efficacy and safety of the synthesized agent are shown in several animal models.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
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