Analysis of the Relationship between Activity of the Reticular Formation of the Medulla Oblongata and the Respiratory and Cardiovascular Systems in Rats under Painful Stimulation

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2024-03-18 DOI:10.1134/S0006350923060064

O. E. Dick

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Abstract

Using a method based on averaging the conditional probabilities of recurrence intervals, a comparative analysis was performed to estimate the direction of coupling between different physiological rhythms (fluctuations in blood pressure, respiration, and neuronal activity in the reticular formation of the medulla oblongata) in two groups of anesthetized rats with or without painful stimulation. Different variants were observed for the directions of coupling between the rhythms. A statistically significant unidirectionality of coupling was detected with most of the data obtained from rats of the control group and rats with experimentally induced colitis. Painful stimulation did not affect the direction of coupling, but slightly reduced the amount of data with unidirectional coupling. Rhythms associated with the cardiovascular system (blood pressure variability) were controlled by rhythms of the respiratory system, and the respiratory rhythm controlled the variability of neuronal activity in the reticular formation of the medulla oblongata.

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疼痛刺激下大鼠延髓网状结构的活动与呼吸系统和心血管系统的关系分析

摘要采用一种基于重复间隔条件概率平均的方法，对两组麻醉大鼠在有或没有疼痛刺激的情况下不同生理节律（血压波动、呼吸和延髓网状结构中的神经元活动）之间的耦合方向进行了比较分析。在节律之间的耦合方向上观察到了不同的变异。从对照组大鼠和实验性结肠炎大鼠身上获得的大部分数据都发现了具有统计学意义的单向耦合性。疼痛刺激并不影响耦合的方向，但略微减少了单向耦合的数据量。与心血管系统有关的节律（血压变化）受呼吸系统节律的控制，而呼吸节律控制着延髓网状结构中神经元活动的变化。

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.